Distribution of Candida species isolated from blood cultures in hospitals in Osaka, Japan

Morii, Daiichi; Seki, Masafumi; Binongo, José; Ban, Ryoichi; Kobayashi, Atsuko; Sata, Makoto; Hashimoto, Shigeki; Shimizu, Junzo; Morita, Shunji; Tomono, Kazunori

doi:10.1016/j.jiac.2014.05.009

Cited by 24 publications

(20 citation statements)

References 22 publications

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“…Previous studies have shown a geographically changing epidemiology of candidaemia all over the world even in the same country . The candidaemia incidences of our institution were 1.23 episodes/1000 admissions and 3.29 episodes/10 000 inpatient days.…”

Section: Discussionmentioning

confidence: 49%

“…was reported to be the fourth in 2004 and third in 2008 in the Unites States hospitals as the most common causes of central line‐associated bloodstream infections . Recently published studies have reported geographically changing risk factors, mortality rates, species distribution and antifungal susceptibility patterns . There was a wide distribution of candidaemia incidences reported from Turkey in between 2.09 and 12.3 per 1000 intensive care unit admissions in which C. parapsilosis and C. albicans were the predominant species respectively .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology, species distribution, clinical characteristics and mortality of candidaemia in a tertiary care university hospital in Turkey, 2007‐2014

Yeşilkaya

Azap

Aydın

et al. 2017

Mycoses

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Candidaemia still continues to be a serious medical concern and the epidemiology of candidaemia varies according to geographical areas. We aim to determine the incidence, local epidemiology, Candida species distribution and crude mortality rates of candidaemia. We retrospectively evaluated candidaemia episodes in between January 2007 and August 2014. We compared demographic, clinical, microbiological findings and mortality rates of episodes caused by Candida albicans and non-albicans Candida species. Overall the candidaemia incidences were 1.23 episodes/1000 admissions. A significant negative slope among candidaemia episodes and years was determined. Overall C. albicans (54.6%) was the most common species followed by Candida glabrata, Candida tropicalis and Candida parapsilosis respectively. Preinfection hospital stay and length of hospital stay were statistically longer in patients with non-albicans Candida candidaemia than in patients with C. albicans candidaemia. The source of candidaemia was unknown in 52.5% of all episodes. Central venous catheters among non-albicans Candida candidaemia episodes and urinary system among C. albicans candidaemia episodes were common source of candidaemia compared to each other. Previous antifungal therapy preceding candidaemia and concomitant bacteraemia were significantly associated with non-albicans Candida candidaemia. Continuous local surveillance will preserve its pivotal importance in formulating empirical antifungal therapy and improving management of candidaemia.

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Section: Discussionmentioning

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Epidemiology, species distribution, clinical characteristics and mortality of candidaemia in a tertiary care university hospital in Turkey, 2007‐2014

Yeşilkaya

Azap

Aydın

et al. 2017

Mycoses

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“…C. tropicalis infections are commonly associated with malignancy, with some studies reporting higher prevalence among patients with hematologic diseases such as acute myeloid leukemia (Weinberger et al, 2005; Nucci and Colombo, 2007; Tang et al, 2014, 2015; Cornely et al, 2015). Mortality associated with C. tropicalis candidemia in these populations unfortunately remains high, ranging from 30 to 70%, with the highest rates most commonly observed among the elderly (Weinberger et al, 2005; Nucci and Colombo, 2007; Morii et al, 2014; Cornely et al, 2015; Wang et al, 2015). C. krusei is the fourth most common NAC species associated with invasive candidiasis and candidemia, accounting for approximately 2.7% of NAC species isolated across the United States (Pfaller et al, 2014b).…”

Section: Introductionmentioning

confidence: 99%

Azole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species

et al. 2017

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Within the limited antifungal armamentarium, the azole antifungals are the most frequent class used to treat Candida infections. Azole antifungals such as fluconazole are often preferred treatment for many Candida infections as they are inexpensive, exhibit limited toxicity, and are available for oral administration. There is, however, extensive documentation of intrinsic and developed resistance to azole antifungals among several Candida species. As the frequency of azole resistant Candida isolates in the clinical setting increases, it is essential to elucidate the mechanisms of such resistance in order to both preserve and improve upon the azole class of antifungals for the treatment of Candida infections. This review examines azole resistance in infections caused by C. albicans as well as the emerging non-albicans Candida species C. parapsilosis, C. tropicalis, C. krusei, and C. glabrata and in particular, describes the current understanding of molecular basis of azole resistance in these fungal species.

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“…In this regard, Candida glabrata has frequently been reported in Northern Europe and US medical centers [1, 10], whereas Candida parapsilosis and Candida tropicalis are the most common non- albicans species associated with fungemia in Latin America and Asia [11, 12]. Of note, a recent multicenter study in the USA found that C. parapsilosis was the second most commonly encountered non- Candida albicans species [13].…”

Section: Introductionmentioning

confidence: 99%

Outbreak of candidemia caused by fluconazole resistant Candida parapsilosis strains in an intensive care unit

Pinhati¹,

Casulari²,

Souza

et al. 2016

BMC Infect Dis

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BackgroundCandidemia is an increasing problem in tertiary care hospitals worldwide. Here, we report the first outbreak of candidemia caused by fluconazole-resistant C. parapsilosis (FRCP) strains in Brazil.MethodsThis was a cross-sectional study of clinical and microbiological data of all candidemic episodes diagnosed from July 2011 to February 2012 in a 200-bed tertiary care hospital. Initial yeast identification and susceptibility testing were performed using the VITEK 2 - System. Isolates of Candida spp. resistant to fluconazole were sent to a reference laboratory (LEMI-UNIFESP) for further molecular identification and confirmation of resistance by CLSI microdilution test. A multivariate analysis was conducted to identify factors associated with FRCP infection.ResultsWe identified a total of 40 critically ill patients with candidemia (15 women) with a median age of 70 years. The incidence of candidemia was 6 cases/1,000 patients admissions, including 28 cases (70 %) of infection with C. parapsilosis, 21 of which (75 %) were resistant to fluconazole. In only 19 % of FRCP candidemia cases had fluconazole been used previously. The results of our study indicated that diabetes is a risk factor for FRCP candidemia (p = 0.002). Overall, mortality from candidemia was 45 %, and mortality from episodes of FRCP infections was 42.9 %.ConclusionsThe clustering of incident cases in the ICU and molecular typing of strains suggest horizontal transmission of FRCP. Accurate vigilant monitoring for new nosocomial strains of FRCP is required.

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Distribution of Candida species isolated from blood cultures in hospitals in Osaka, Japan

Cited by 24 publications

References 22 publications

Epidemiology, species distribution, clinical characteristics and mortality of candidaemia in a tertiary care university hospital in Turkey, 2007‐2014

Epidemiology, species distribution, clinical characteristics and mortality of candidaemia in a tertiary care university hospital in Turkey, 2007‐2014

Azole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species

Outbreak of candidemia caused by fluconazole resistant Candida parapsilosis strains in an intensive care unit

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