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Cited by 22 publications
(8 citation statements)
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References 27 publications
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“…This possibility, however, leaves open the question of why such a large number of cells in specific anatomical locations would express an unutilized mRNA molecule. Another study using PCR also detected relatively high levels of aromatase mRNA in cortex (Yamada et al, 1994). Interestingly, There are large discrepancies among reports on the aromatase mRNA levels in cortex were low during develop-anatomical localization of aromatase immunoreactivity in ment and then gradually increased to an adult level, rat brain.…”
Section: Discussionmentioning
confidence: 87%
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“…This possibility, however, leaves open the question of why such a large number of cells in specific anatomical locations would express an unutilized mRNA molecule. Another study using PCR also detected relatively high levels of aromatase mRNA in cortex (Yamada et al, 1994). Interestingly, There are large discrepancies among reports on the aromatase mRNA levels in cortex were low during develop-anatomical localization of aromatase immunoreactivity in ment and then gradually increased to an adult level, rat brain.…”
Section: Discussionmentioning
confidence: 87%
“…The probe used in the present study is transcribed from cDNA taken from rat ovarian granulosa cells, whereas the probe used by Abdelgadir et al (1994) for the RNase protection assay is transcribed from the cDNA taken from a Leydig cell tumor line (Lephart et al, 1990). Reports using RT-PCR (Yamada et al, 1994) have demonstrated that the sequence of the PCR product in rat brain is identical to that of the ovarian cDNA and differs from the tumor cell cDNA. This implies that mutations in the aromatase gene may have occurred in the tumor line and that probes generated from this cDNA may differ in sequence from aromatase mRNA in brain.…”
Section: Discussionmentioning
confidence: 96%
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“…Aromatase activity and mRNA reach peak levels in late fetal development of the rat [12][13][14][15][16][17][18][19], In addition, ear lier studies have demonstrated that aromatase activity in male rodents during perinatal development is generally higher as the comparable levels in female animals [14-18, 20, 21]. In rats, the observed sex differences of enzyme activity appear to be most pronounced in early postnatal stages of development [14][15][16][17][18].…”
Section: Introductionmentioning
confidence: 99%
“…With immunohistochemical techniques, the presence of aromatase has been demonstrated in several nerve centers (Shinoda et al 1989(Shinoda et al , 1990Balthazart et al 1990Balthazart et al , 1991Sanghera et al 1991;Segovia and Guillamón 1993;Dellovade et al 1994;Tsuruo et al 1994;Yamada et al 1994;Foidart et al 1995). In particular, the enzyme has been described in the dorsal area, in the medial preoptic area, and in the paraventricular and ventromedial nuclei of the hypothalamus (Foidart et al 1994(Foidart et al , 1995.…”
mentioning
confidence: 97%