Distribution and covalent interactions of [1-14C]acrylonitrile in the rat

التغيرات الفسيولوجية الهرمونية للخصية الناتجة عن التعرض لسيانيد الفينيل والدور الوقائي المحتمل لـلبيتاكريبتوزانثين في ذكور الجرذان

“…From these results it is clear that vinyl cyanide has been demonstrated to induce male reproductive toxicity in laboratory animals (Ahmed et al, 1992;Liu et al, 2004) and also in VCNexposed workers (Xu et al, 2003). Whole body autoradiography and toxicokinetic studies showed that the brain is a target organ for VCN toxicity (Ahmed et al, 1982). (McLachlan et al, 2002)reported that endo crine support is essential for normal spermatogenesis and disturbance can lead to altered spermatogenesis in both humans and rodents.…”

التغيرات الفسيولوجية الهرمونية للخصية الناتجة عن التعرض لسيانيد الفينيل والدور الوقائي المحتمل لـلبيتاكريبتوزانثين في ذكور الجرذان

“…From these results it is clear that vinyl cyanide has been demonstrated to induce male reproductive toxicity in laboratory animals (Ahmed et al, 1992;Liu et al, 2004) and also in VCNexposed workers (Xu et al, 2003). Whole body autoradiography and toxicokinetic studies showed that the brain is a target organ for VCN toxicity (Ahmed et al, 1982). (McLachlan et al, 2002)reported that endo crine support is essential for normal spermatogenesis and disturbance can lead to altered spermatogenesis in both humans and rodents.…”

To what extent are biomonitoring data available in chemical risk assessment?

“…Table 2 also summarizes the animal data on urinary metabolites and on percutaneous penetration ability of the twelve chemicals. The main urinary metabolites have been identi®ed for eight chemicals: styrene, 37 ± 42 trichloroethylene, 43 ± 45 acrylonitrile, 46 buta-1,3-diene, 47 cyclohexane, 48,49 1-4 dichlorobenzene, 50,51 hydrogen¯uoride 52 and 2-(2methoxyethoxy)ethanol. 32 They are generally the same as those detected in human urine, at least qualitatively, and this con®rms both the predictive value of animal metabolism studies, and their interest in the development of new bioindicators of exposure.…”

Hesperidin, an antioxidant flavonoid, prevents acrylonitrile‐induced oxidative stress in rat brain

“…Binding of ACN to these antioxidants, especially GSH, results in the induction of oxidative stress and impaired regeneration of other antioxidants [32]. Studies with 14 C ACN have shown that ACN covalently binds with sulfhydryl groups of protein [38] and to tissue macromolecules and nucleic acids [39]. This explains the reduction in the GSH content of tissues.…”

التغيرات الفسيولوجية الهرمونية للخصية الناتجة عن التعرض لسيانيد الفينيل والدور الوقائي المحتمل لـلبيتاكريبتوزانثين في ذكور الجرذان

“…From these results it is clear that vinyl cyanide has been demonstrated to induce male reproductive toxicity in laboratory animals (Ahmed et al, 1992;Liu et al, 2004) and also in VCNexposed workers (Xu et al, 2003). Whole body autoradiography and toxicokinetic studies showed that the brain is a target organ for VCN toxicity (Ahmed et al, 1982). (McLachlan et al, 2002)reported that endo crine support is essential for normal spermatogenesis and disturbance can lead to altered spermatogenesis in both humans and rodents.…”

To what extent are biomonitoring data available in chemical risk assessment?

“…Table 2 also summarizes the animal data on urinary metabolites and on percutaneous penetration ability of the twelve chemicals. The main urinary metabolites have been identi®ed for eight chemicals: styrene, 37 ± 42 trichloroethylene, 43 ± 45 acrylonitrile, 46 buta-1,3-diene, 47 cyclohexane, 48,49 1-4 dichlorobenzene, 50,51 hydrogen¯uoride 52 and 2-(2methoxyethoxy)ethanol. 32 They are generally the same as those detected in human urine, at least qualitatively, and this con®rms both the predictive value of animal metabolism studies, and their interest in the development of new bioindicators of exposure.…”

Hesperidin, an antioxidant flavonoid, prevents acrylonitrile‐induced oxidative stress in rat brain

“…Binding of ACN to these antioxidants, especially GSH, results in the induction of oxidative stress and impaired regeneration of other antioxidants [32]. Studies with 14 C ACN have shown that ACN covalently binds with sulfhydryl groups of protein [38] and to tissue macromolecules and nucleic acids [39]. This explains the reduction in the GSH content of tissues.…”

التغيرات الفسيولوجية الهرمونية للخصية الناتجة عن التعرض لسيانيد الفينيل والدور الوقائي المحتمل لـلبيتاكريبتوزانثين في ذكور الجرذان

“…From these results it is clear that vinyl cyanide has been demonstrated to induce male reproductive toxicity in laboratory animals (Ahmed et al, 1992;Liu et al, 2004) and also in VCNexposed workers (Xu et al, 2003). Whole body autoradiography and toxicokinetic studies showed that the brain is a target organ for VCN toxicity (Ahmed et al, 1982). (McLachlan et al, 2002)reported that endo crine support is essential for normal spermatogenesis and disturbance can lead to altered spermatogenesis in both humans and rodents.…”

To what extent are biomonitoring data available in chemical risk assessment?

“…Table 2 also summarizes the animal data on urinary metabolites and on percutaneous penetration ability of the twelve chemicals. The main urinary metabolites have been identi®ed for eight chemicals: styrene, 37 ± 42 trichloroethylene, 43 ± 45 acrylonitrile, 46 buta-1,3-diene, 47 cyclohexane, 48,49 1-4 dichlorobenzene, 50,51 hydrogen¯uoride 52 and 2-(2methoxyethoxy)ethanol. 32 They are generally the same as those detected in human urine, at least qualitatively, and this con®rms both the predictive value of animal metabolism studies, and their interest in the development of new bioindicators of exposure.…”

Hesperidin, an antioxidant flavonoid, prevents acrylonitrile‐induced oxidative stress in rat brain

“…Binding of ACN to these antioxidants, especially GSH, results in the induction of oxidative stress and impaired regeneration of other antioxidants [32]. Studies with 14 C ACN have shown that ACN covalently binds with sulfhydryl groups of protein [38] and to tissue macromolecules and nucleic acids [39]. This explains the reduction in the GSH content of tissues.…”