volume 192, issue 8, P3676-3685 2014
DOI: 10.4049/jimmunol.1300837
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Aaron J. Tyznik, Shilpi Verma, Qiao Wang, Mitchell Kronenberg, Chris A. Benedict

Abstract: Natural killer (NK) cells are key regulators of innate defense against mouse cytomegalovirus (MCMV). Like NK cells, NKT cells also produce high levels of IFNγ rapidly after MCMV infection. However, whether similar mechanisms govern activation of these two cell-types, and the significance of NKT cells for host resistance, remain unknown. Here we show that although both NKT and NK cells are activated via cytokines, their particular cytokine requirements differ significantly, in vitro and in vivo. IL-12 is requi…

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