Distinct Microbiota Dysbiosis in Patients with Non-Erosive Reflux Disease and Esophageal Adenocarcinoma

Zhou, Jerry; Shrestha, Prapti; Qiu, Zhiguang; Harman, David G.; Teoh, Wun-Chung; Al–Sohaily, Sam; Liem, Han; Turner, Ian; Ho, Vincent

doi:10.3390/jcm9072162

Cited by 32 publications

(54 citation statements)

References 59 publications

(66 reference statements)

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“…the relative abundance of Dorea, Bilophila, and Sulfurovum in the WB treatment was higher than that in the X and XO treatments. Dorea is a hydrogen producer (Zhou et al, 2020), Bilophila is a potential pathogen and detrimental bacteria (Toe et al, 2020), and Sulfurovum is related to sulfur metabolism (Mori et al, 2018). Furthermore, it has been reported that WB promoted steatosis and adipose tissue inflammation (Suriano et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Xylooligosaccharide, Xylan, and Whole Wheat Bran on the Human Gut Bacteria

et al. 2020

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Wheat bran is a cereal rich in dietary fibers that have high levels of ferulic acid, which has prebiotic effects on the intestinal microbiota and the host. Herein we explored the effect of xylooligosaccharide, xylan, and whole wheat bran on the human gut bacteria and screened for potential ferulic acid esterase genes. Using in vitro fermentation, we analyzed the air pressure, pH-value, and short-chain fatty acid levels. We also performed 16S rRNA gene and metagenomic sequencing. A Venn diagram analysis revealed that 80% of the core operational taxonomic units (OTUs) were shared among the samples, and most of the xylooligosaccharide treatment core OTUs (319/333 OTUs) were shared with the other two treatments’ core OTUs. A significant difference analysis revealed that the relative abundance of Dorea, Bilophila, and Sulfurovum in wheat bran treatment was higher than that in xylan and xylooligosaccharide treatments. The clusters of orthologous groups of proteins functional composition of all samples was similar to the microbiota composition of the control. Using metagenomic sequencing, we revealed seven genes containing the conserved residues, Gly-X-Ser-X-Gly, and the catalytic triad, Ser-His-Asp, which are thus potential ferulic acid esterase genes. All the results indicate that xylan and/or xylooligosaccharide, the main dietary fibers in wheat bran, plays a major role in in vitro fermentation by the human gut microbiota.

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Section: Discussionmentioning

confidence: 99%

The Effect of Xylooligosaccharide, Xylan, and Whole Wheat Bran on the Human Gut Bacteria

et al. 2020

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“…In the distal esophagus, the effect of PPIs may be more likely to be due to microbial related inflammatory changes, whereas previously attributed to direct acid contact mucosal injury. A study of patients with non-erosive reflux disease (NERD), erosive GERD, and BE compared PPI use vs no use within each respective group and found no change in α diversity or β diversity between PPI and non-PPI users of each group was reported, but composition of specific bacteria taxa at the phylum level was noted[ 53 ]. In particular, PPI use was associated with an increase in Firmicutes and Proteobacteria in BE, and a decrease in Bacteroidetes in NERD and reflux esophagitis (RE)[ 53 ].…”

Section: Normal Gastroesophageal Microfloramentioning

confidence: 99%

“…A study of patients with non-erosive reflux disease (NERD), erosive GERD, and BE compared PPI use vs no use within each respective group and found no change in α diversity or β diversity between PPI and non-PPI users of each group was reported, but composition of specific bacteria taxa at the phylum level was noted[ 53 ]. In particular, PPI use was associated with an increase in Firmicutes and Proteobacteria in BE, and a decrease in Bacteroidetes in NERD and reflux esophagitis (RE)[ 53 ]. In another study, biopsies taken before and after 8 wk of PPI treatment (lansoprazole 30 mg twice daily) revealed a significant decrease in the gram-negative Comamonadaceae spp.…”

Section: Normal Gastroesophageal Microfloramentioning

confidence: 99%

“…and Bacteroidetes ( Bacteroides uniformis, Capnocytophaga spp. , and Prevotella pallens ), and away from Fusobacteria ( Leptotrichia ) and Actinobacteria ( Rothia )[ 53 ]. Several Firmicutes genera were reduced in NERD ( Peptococcus and Moryella ).…”

Section: Dysbiosis In Disease Statesmentioning

confidence: 99%

“…Several Firmicutes genera were reduced in NERD ( Peptococcus and Moryella ). An increased abundance of Dorea spp., however, resulted in an overall higher Firmicutes composition compared with controls[ 53 ]. The same study speculated that the increase in sulfate-reducing Proteobacteria spp.…”

Section: Dysbiosis In Disease Statesmentioning

confidence: 99%

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Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease: A paradigm shift from acid to bacteria?

D’Souza¹,

Houston²,

Keenan³

et al. 2021

WJG

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Genomic sequencing, bioinformatics, and initial speciation ( e.g. , relative abundance) of the commensal microbiome have revolutionized the way we think about the “human” body in health and disease. The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases, including those impacting the esophagus. Although relatively stable, there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome (EM) and the host. These changes are thought to be a product of age, diet, antibiotic and other medication use, oral hygiene, smoking, and/or expression of antibiotic products (bacteriocins) by other flora. These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation, systemic inflammation, and ultimately disease progression. Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is, therefore, not merely the result of esophageal mucosal exposure to corrosives ( i.e. , acid). Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade. Here, we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief ( i.e. , acid suppression).

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Epidemiology, Microbiome, and Risk Factors Involved in Carcinogenesis of Esophagus, Gastric, and Intestine

Chew,

Yim,

Ali

et al. 2024

Gastrointestinal Oncology ‐ a Critical Multidisciplinary Team Approach 2e

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Distinct Microbiota Dysbiosis in Patients with Non-Erosive Reflux Disease and Esophageal Adenocarcinoma

Cited by 32 publications

References 59 publications

The Effect of Xylooligosaccharide, Xylan, and Whole Wheat Bran on the Human Gut Bacteria

The Effect of Xylooligosaccharide, Xylan, and Whole Wheat Bran on the Human Gut Bacteria

Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease: A paradigm shift from acid to bacteria?

Epidemiology, Microbiome, and Risk Factors Involved in Carcinogenesis of Esophagus, Gastric, and Intestine

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