Distinct germinal center selection at local sites shapes memory B cell response to viral escape

Abstract

Local germinal center reactions that persist in the lung after influenza infection are required for the generation of cross-reactive memory B cells.

Robust memory responses against influenza vaccination in pemphigus patients previously treated with rituximab

“…Based on a previous observation in splenectomized immune thrombocytopenia patients that revealed the presence of persisting antigen-specific MBCs in the spleen (14, 51), we believe it is likely that this diverse pool of cells survives in tissues. Additionally, a recent study showed that tissue-resident MBCs in a mouse model are enriched for broadly neutralizing influenza-specific antibodies compared with those in circulation (52). If influenza vaccine responses in patients are originating from a diverse pool of tissue-resident MBCs, this mouse study could potentially explain how patients are able to mount a protective response to vaccination despite the low number of MBCs.…”

CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer

“…De novo TLS formation in chronically inflamed tissues has been correlated with allograft rejection, autoimmune disease progression (9), and improved cancer outcomes (10). Influenza-induced TLS in the lung (but not nearby secondary lymphoid organs) and the subsequent generation of resident memory B cells were responsible for limiting virus escape after infection (11). In some tissues, in vivo TLS formation can be initiated by mature …”

Whole-Virion Influenza Vaccine Recalls an Early Burst of High-Affinity Memory B Cell Response through TLR Signaling

“…Therefore, by using fluorescent HA probes, we first sought to trace virus-specific memory B cell responses after s.c. vaccination as previously reported ( Fig. 1) (23,24). We selected whole-virion vaccines of the H5N1 subtype for this study, because this is the only whole-virion vaccine currently stockpiled in Japan for humans.…”