Distinct evolution of infection-enhancing and neutralizing epitopes in the spike protein of SARS-CoV-2 variants (alpha, beta, gamma, delta, lambda and µ) : a structural and molecular epidemiology study
Abstract:Objectives. The efficiency of Covid-19 vaccination is determined by
cellular and humoral immune responses, and for the latter, by the
balance between neutralizing and infection-enhancing antibodies. Here we
analyzed the evolution of neutralizing and facilitating epitopes in the
spike protein among SARS-CoV-2 variants. Methods. Amino acid alignments
were performed on 929,203 spike sequences over the 4 last months.
Molecular modeling studies of the N-terminal domain (NTD) and rod-like
regions of the spike protei… Show more
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