Distinct Effect of CD40 and TNF-Signaling on the Chemokine/Chemokine Receptor Expression and Function of the Human Monocyte-Derived Dendritic Cells

Xia, Yu; Jun, Dai; Lu, Peirong; Huang, Yong; Zhu, Yipei; Zhang, Xueguang

doi:10.1038/cmi.2008.15

Cited by 10 publications

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, CD4+ T EM cells gain access to reactive LNs via CXCR3-independent means to interact with DCs and increase future T cell priming through CD40 upregulation [49]. Once T EM cells enter the LN, it is unknown if CD8+ or CD4+ interactions with DCs are also dependent on CXCR3 and its ligands, although it has been shown that CD40L stimulated DCs increase expression of CXCL10 [77]. Future studies into the role of CXCR3-dependent interactions in the development of primary, secondary and contraction of adaptive immune responses will therefore yield interesting results with applications for vaccinology.…”

Section: Cxcr3 In the Induction And Recall Of Immune Responsesmentioning

confidence: 99%

CXCR3 in T cell function

Groom¹,

Luster²

2011

Experimental Cell Research

780

648

View full text Add to dashboard Cite

CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells following activation and preferentially remains highly expressed on Th1-type CD4+ T cells and effector CD8+ T cells. CXCR3 is activated by three interferon-inducible ligands CXCL9 (MIG), CXCL10 (IP-10) and CXCL11 (I-TAC). Early studies demonstrated a role for CXCR3 in the trafficking of Th1 and CD8 T cells to peripheral sites of Th1-type inflammation and the establishment on Th1 amplification loop mediated by IFNγ and the IFNγ-inducible CXCR3 ligands. More recent studies have also suggested that CXCR3 plays a role in the migration of T cells in the microenvironment of the peripheral tissue and lymphoid compartment, facilitating the interaction of T cells with antigen presenting cells leading to the generation of effector and memory cells.

show abstract

Section: Cxcr3 In the Induction And Recall Of Immune Responsesmentioning

confidence: 99%

CXCR3 in T cell function

Groom¹,

Luster²

2011

Experimental Cell Research

780

648

View full text Add to dashboard Cite

show abstract

“…In previous studies, different maturation methods caused differences in the type and characteristics of mDCs generated; indeed, the maturation signal can determine the type of the immune response (Krause et al 2007;Savina and Amigorena 2007;Ten Brinke et al 2007;Xia et al 2008). Among all methods, TNF-␣ and bacterial lipopolysaccharide (LPS) at different concentrations are the most frequently used single agents for maturation of DCs in vitro.…”

Section: Introductionmentioning

confidence: 98%

Dendritic cells matured by a prostaglandin E2-containing cocktail can produce high levels of IL-12p70 and are more mature and Th1-biased than dendritic cells treated with TNF-α or LPS

2011

View full text Add to dashboard Cite

“…IP-10 is also induced through cell-surface receptor interaction with T-cells [105][106][107][108][109][110]. IP-10 shares the chemokine (C-X-C motif) receptor (CXCR)3 with MIG and IFN-inducible T-cell a chemoattractant (I-TAC), an important receptor involved in the regulation of innate and adaptive immune responses through chemotaxis, cell growth and angiostasis [108,[111][112][113].…”

Section: Ip-10mentioning

confidence: 99%

Beyond the IFN- horizon: biomarkers for immunodiagnosis of infection with Mycobacterium tuberculosis

Chegou

Heyckendorf

Walzl

et al. 2013

European Respiratory Journal

147

123

View full text Add to dashboard Cite

Latent infection with Mycobacterium tuberculosis (LTBI) is defined by the presence of M. tuberculosis-specific immunity in the absence of active tuberculosis. LTBI is detected using interferon-c release assays (IGRAs) or the tuberculin-skin-test (TST). In clinical practice, IGRAs and the TSTs have failed to distinguish between active tuberculosis and LTBI and their predictive value to identify individuals at risk for the future development of tuberculosis is limited.There is an urgent need to identify biomarkers that improve the clinical performance of current immunodiagnostic methods for tuberculosis prevention, diagnosis and treatment monitoring. Here, we review the landscape of potential alternative biomarkers useful for detection of infection with M. tuberculosis. We describe what individual markers add in terms of specificity for active/latent infection, prediction of progression to active tuberculosis and immunodiagnostic potential in high-risk groups' such as HIV-infected individuals and children. @ERSpublications The field of biomarkers for the guidance of clinical management of patients with tuberculosis is rapidly evolving

show abstract

Distinct Effect of CD40 and TNF-Signaling on the Chemokine/Chemokine Receptor Expression and Function of the Human Monocyte-Derived Dendritic Cells

Cited by 10 publications

References 34 publications

CXCR3 in T cell function

CXCR3 in T cell function

Dendritic cells matured by a prostaglandin E2-containing cocktail can produce high levels of IL-12p70 and are more mature and Th1-biased than dendritic cells treated with TNF-α or LPS

Beyond the IFN- horizon: biomarkers for immunodiagnosis of infection with Mycobacterium tuberculosis

Contact Info

Product

Resources

About