Distant metastases in head and neck cancer patients who achieved loco-regional control

León, Xavier; Quer, Miquel; Orús, César; Venegas, María del Prado; López, Montserrat

doi:10.1002/1097-0347(200010)22:7<680::aid-hed7>3.0.co;2-j

Cited by 222 publications

(182 citation statements)

References 24 publications

(47 reference statements)

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“…Since not only the suppression of primary lesion but also the presence or absence of metastasis in the distant organs may greatly influence the outcome of oral cancer, suppression of metastasis has become an important subject 1) . However, the therapeutic regimen has been selected mainly based on the stage of clinical progression in most cases.…”

Section: Introductionsupporting

confidence: 87%

An Analysis of Distant Metastases in Oral Squamous Cell Carcinoma

Yasui¹,

Okada²,

Mataga³

et al. 2010

J. Hard Tissue Biology.

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Metastases to distant organs are well known to be factors influencing prognosis in patients with oral cancer. Therefore, it is very important to detect the metastasis of cancer as early as possible and to investigate the factors associated with the mechanism of metastasis. This study evaluated the risk of distant metastasis by the degree of histological malignancy among 59 patients with oral squamous cell carcinoma (SCC) who were treated at our department during the past five years. The degree of histological malignancy of initial biopsy specimens was evaluated by Anneroth's classification and its relationship with metastasis was analyzed. Distant metastasis occurred in 7 of 59 patients (11.9%) and was located predominantly in the lung and bone. There was a significant correlation between the degree of histological malignancy and distant metastasis (P<0.05); however, there was no significant difference between T classification and metastasis in the distant organs. It is considered that histological malignancy is useful for predicting the prognosis and deciding additional treatments for oral SCC. When a total score on histological malignancy grading exceeds 14, metastasis in the distant organs should be carefully considered.

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Section: Introductionsupporting

confidence: 87%

An Analysis of Distant Metastases in Oral Squamous Cell Carcinoma

Yasui¹,

Okada²,

Mataga³

et al. 2010

J. Hard Tissue Biology.

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“…The major reason for this discrepancy is distant metastasis and second neoplasms (6). The incidence of clinically detected distant metastasis of the head and neck ranges from 11% to 23%, and most of the metastasis are observed in the lymph nodes and lungs (7).…”

Section: Introductionsupporting

confidence: 85%

Role of Myeloid Cell Leukemia-1 in Cell Growth of Squamous Cell Carcinoma

et al. 2009

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“…Nevertheless, overall survival remains largely unchanged (2,3). The major reason for this discrepancy is distant metastasis and second neoplasms (4). The incidence of clinically detected distant metastasis of the head and neck ranges from 11% to 23% and most of the metastasis are observed in the lymph nodes and lungs (5).…”

mentioning

confidence: 99%

Critical Role of Peroxisome Proliferator-Activated Receptor γ on Anoikis and Invasion of Squamous Cell Carcinoma

Masuda

Wada

Nakajima

et al. 2005

Clinical Cancer Research

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Purpose: Peroxisome proliferator-activated receptor g (PPARg) plays a important role in various physiological functions.We examined whether PPARg is expressed in primary squamous cell carcinoma and lymph node metastasis and whether PPARg is a potential target for tumor therapy. Experimental Design and Results: A high-level expression of PPARg was observed in tumor cells of human primary squamous cell carcinoma, lymph node metastasis, and squamous cell carcinoma cell lines. Treatment with PPARg-specific antagonists, but not agonists, caused apoptotic cell death on squamous cell carcinoma cell lines in a concentration-dependent manner. Small interfering RNA for PPARg also inhibited cell adhesion and growth of squamous cell carcinomas. The phosphorylation of focal adhesion kinase (FAK) was decreased by treatment with PPARg antagonists, and resulted in decreases in phosphorylation of Erk and mitogen-activated protein kinase. Furthermore, PPARg antagonists decreased the adhesion of squamous cell carcinomas into fibronectin-coated plates, indicating the inhibition of interaction between squamous cell carcinomas and fibronectin. Expression of integrin a5, a counter adhesion molecule for fibronectin, was inhibited by the treatment with PPARg antagonists.These results indicate that the decrease in integrin a5 and following inhibition of cell adhesion may cause the inhibition of FAK signaling pathways. PPARg antagonists also strongly inhibited invasion of squamous cell carcinoma via down-regulation of CD151expression. Conclusions: The cell death caused by the PPARg antagonists was a result of direct interference with cell adhesion ''anoikis'' involving intracellular FAK signaling pathways. These results imply a potentially important and novel role for the inhibition of PPARg function via the use of specific antagonists in the treatment of squamous cell carcinoma and the prevention of tumor invasion and metastasis.

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Distant metastases in head and neck cancer patients who achieved loco-regional control

Cited by 222 publications

References 24 publications

An Analysis of Distant Metastases in Oral Squamous Cell Carcinoma

An Analysis of Distant Metastases in Oral Squamous Cell Carcinoma

Role of Myeloid Cell Leukemia-1 in Cell Growth of Squamous Cell Carcinoma

Critical Role of Peroxisome Proliferator-Activated Receptor γ on Anoikis and Invasion of Squamous Cell Carcinoma

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