Distant metastases from head and neck squamous cell carcinomas

Calhoun, Karen H.; Fulmer, Paul; Weiss, Raymond L.; Hokanson, Jim

doi:10.1288/00005537-199410000-00003

Cited by 190 publications

(149 citation statements)

References 24 publications

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“…Distant metastasis was reported in 5-25% of OSCC patients [29] most commonly in poor locoregional control. Distance metastasis is usually reported in N2/N3.…”

Section: Lymph Node Involvementmentioning

confidence: 99%

The Outline of Prognosis and New Advances in Diagnosis of Oral Squamous Cell Carcinoma (OSCC): Review of the Literature

Omar

2013

Journal of Oral Oncology

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Objective. Oral squamous cell carcinoma (OSCC) has a remarkable incidence over the world and a fairly strenuous prognosis, encouraging further research on the prognostic factors and new techniques for diagnosis that might modify disease outcome. Data Sources. A web-based search for all types of articles published was initiated using Medline/Pub Med, with the key words such as oral cancer, prognostic factors of oral cancer, diagnostic method of oral cancer, and imaging techniques for diagnosis of oral cancer. The search was restricted to articles published in English, with no publication date restriction (last update April, 2013). Review Methods. In this paper, I approach the factors of prognosis of OSCC and the new advances in diagnostic technologies as well. I also reviewed available studies of the tissue fluorescence spectroscopy and other noninvasive diagnostic aids for OSCC. Results. The outcome is greatly influenced by the stage of the disease (especially TNM). Prognosis also depends or varies with tumour primary site, nodal involvement, tumour thickness, and the status of the surgical margins. Conclusion. Tumour diameter is not the most accurate when compared to tumour thickness or depth of invasion, which can be related directly to prognosis. There is a wide agreement on using ultrasound guided fine needle aspiration biopsies in the evaluation of lymph node metastasis.

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“…Distant metastasis was reported in 5-25% of OSCC patients [29] most commonly in poor locoregional control. Distance metastasis is usually reported in N2/N3.…”

Section: Lymph Node Involvementmentioning

confidence: 99%

The Outline of Prognosis and New Advances in Diagnosis of Oral Squamous Cell Carcinoma (OSCC): Review of the Literature

Omar

2013

Journal of Oral Oncology

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“…Mutations were found in either one or both tumors in 15 patients, which allowed differentiation between SPT and DM. Nine patients were classified as SPT (patients [1][2][3][4][5][6][7][8][9] and six as DM (patients 10-15). In patients 1, 2, 5, 6, 7, and 9, we found a TP53 mutation in the HNSCC and wild-type TP53 in the lung carcinoma.…”

Section: Translational Relevancementioning

confidence: 99%

“…SPT most frequently occur in the head and neck region, with the lungs as the second most common site (2,3). The lungs are also the most common site of DM in patients with head and neck squamous cell carcinoma (HNSCC), causing a problem in differential diagnosis (4). Early detection and treatment of small size primary lung carcinoma improves survival (5,6).…”

mentioning

confidence: 99%

Differential Diagnosis of Pulmonary Carcinoma Following Head and Neck Cancer by Genetic Analysis

Geurts

Velthuysen

Broekman

et al. 2009

Clinical Cancer Research

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Purpose: Patients with head and neck cancer often develop a lung tumor that can be diagnosed as distant metastasis (DM) or second primary tumor (SPT). In this study, we useTP53 mutation analysis for validation of an allelic loss marker panel and a decision algorithm for distinguishing between DM and SPT. Experimental Design: Tumor pairs of 39 patients were analyzed for TP53 mutations, for patterns of allelic loss and immunohistochemical analysis of p53 expression. Results of these three analyses were compared, using mutation analysis as gold standard. Results: Loss of heterozygosity (LOH) analysis indicated DM in 15 and SPT in 23 cases (one inconclusive). TP53 mutation analysis was informative in 15 cases. Based on the p53 mutation status alone, nine tumors were diagnosed as SPT and six as DM. In all 15 cases the LOH analysis was in concordance with the TP53 mutation analysis. Immunostaining for p53 showed promise as a first scan to diagnose lung tumors as SPT but cannot be used to diagnose DM. Conclusion: The TP53 mutation data validate the suitability of the LOH marker panel and decision algorithm for differential diagnosis of DM and SPT in the lung. LOH analysis can theoretically be exploited in almost all cases and is less laborious thanTP53 mutation analysis.

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“…The four criteria used to determine suitability for surgical resection of pulmonary metastases were [1] presence of metastasis from a malignant tumor in the head or neck (excepting the thyroid), [2] complete response to radical therapy for the primary lesion and sustained complete remission of cancer thereafter, [3] no other distant metastases, and [4] complete pulmonary resection not contraindicated. We retrospectively reviewed treatment outcomes for these 16 cases of resected pulmonary metastases and attempted to identify clinicopathologic factors associated with prognosis.…”

Section: Methodsmentioning

confidence: 99%

“…Nevertheless, despite adequate local control, distant metastases frequently develop and are associated with unfavorable outcomes [1,2]. The most common metastasis of head and neck carcinoma is hematogenous metastasis to the lungs; however, there are few data on survival rates after metastasectomy, and treatment in most reported cases did not include surgical resection of distant metastases.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Outcome After Resection of Pulmonary Metastasis from Head and Neck Carcinomas

Yamazaki

Shodo

Ueki

et al. 2014

Indian J Otolaryngol Head Neck Surg

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Hematogenous metastasis is the most common form of metastasis in head and neck cancer, and reports have described successful resection of pulmonary metastases of such cancers. We report treatment outcomes after surgical resection of pulmonary metastases of head and neck cancer and identify prognostic factors. This clinicopathologic study investigated the clinical records of 16 patients with pulmonary metastases of head and neck cancer (excepting cases of thyroid cancer) who had undergone metastasectomy at our center during the period 2001-2012. The mean age of the 16 patients (11 men and 5 women) was 62.1 years. The mean interval between completion of successful treatment of the primary tumor and detection of pulmonary metastasis was 21 months (range, 6-56 months). All patients underwent pulmonary resection. The overall 1-year survival rate was 79.4 %, and the 2-to 5-year survival rate was 63.2 %. These rates compare favorably to those in previous reports on resection of pulmonary metastases. When prognostic factors for survival rates were compared, the factors associated with a negative prognosis were a disease-free interval of \12 months and partial resection of pulmonary metastases. Multivariate analysis did not reveal any prognostic factors associated with negative outcomes. Surgical resection of pulmonary metastases of head and neck cancer might improve outcomes.

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Distant metastases from head and neck squamous cell carcinomas

Cited by 190 publications

References 24 publications

The Outline of Prognosis and New Advances in Diagnosis of Oral Squamous Cell Carcinoma (OSCC): Review of the Literature

The Outline of Prognosis and New Advances in Diagnosis of Oral Squamous Cell Carcinoma (OSCC): Review of the Literature

Differential Diagnosis of Pulmonary Carcinoma Following Head and Neck Cancer by Genetic Analysis

Therapeutic Outcome After Resection of Pulmonary Metastasis from Head and Neck Carcinomas

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