“…There is no single cause for OA, but a number of factors that seem to correlate highly with its existence include age, systemic issues, acute trauma, weight, genetic predisposition, and mechanical stress (Zimmerman and Kelley, 1982;Steele and Bramblett, 1988;Brandt, 1996;Larsen, 1997;Blackburn, 1999;Jurmain, 1999;Cox and Mays, 2000;Hannan, 2001). Osteoarthritis often first affects the large weight-bearing joints of the body but also the interphalangeal joints in the fingers (Plato and Norris, 1979) and the trapeziometacarpal (TMC) joint of the thumb (Brandt, 1996;Bouchlis, 1997;Blackburn, 1999;Jurmain, 1999;Lozada and Altman, 2001).…”