Dissolution of Urinary Bladder Clots in a Dog with Alteplase

Pineda, Carmen; Guisado, Alicia; Aguilera–Tejero, Escolástico; López, Isabel

doi:10.1111/jvim.13637

Cited by 5 publications

(9 citation statements)

References 6 publications

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“…Die Erkrankung kann ein-oder beidseitig auftreten und zu mikro-oder makroskopischer Hämaturie führen (50,54). Junghunde großer Rassen sind häufiger betroffen (17,54,94). Die IRH ist mitunter schwierig zu diagnostizieren, in der Regel erfolgt die Diagnose zystoskopisch (Abb.…”

Section: Idiopathische Renale Hämaturie (Irh)unclassified

“…S1) 1 (17,50,54). Obwohl die IRH meist gutartig verläuft, besteht langfristig das Risiko einer Anämie, eines Eisenmangels und einer obstruktiven Uropathie (17,94).…”

Section: Idiopathische Renale Hämaturie (Irh)unclassified

“…Medikamentös (Yunnan Baiyao, ε-Aminocapronsäure) lässt sich die IRH in der Regel nicht erfolgreich behandeln (17,50,94). Die Ureteronephrektomie gilt heute als obsolet, da bei einseitiger Erkrankung später auch die kontralaterale Niere betroffen sein kann (17,54).…”

Section: Idiopathische Renale Hämaturie (Irh)unclassified

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Minimal-invasive interventionelle Verfahren am Urogenitaltrakt von Hund und Katze

Heilmann¹

2016

Tierarztl Prax Ausg K

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KeywordsBypass, stent, endoscopy, interventional radiology, catheter, obstruction, stricture SummaryMinimally invasive interventional techniques are advancing fast in small animal medicine. These techniques utilize state-of-the-art diagnostic methods, including fluoroscopy, ultrasonography, endoscopy, and laparoscopy. Minimally invasive procedures are particularly attractive in the field of small animal urology because, in the past, treatment options for diseases of the urogenital tract were rather limited or associated with a high rate of complications. Most endourological interventions have a steep learning curve. With the appropriate equipment and practical training some of these procedures can be performed in most veterinary practices. However, most interventions require referral to a specialty clinic. This article summarizes the standard endourological equipment and materials as well as the different endourological interventions performed in dogs and cats with diseases of the kidneys/renal pelves, ureters, or lower urinary tract (urinary bladder and urethra). Korrespondenzadresse

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Section: Idiopathische Renale Hämaturie (Irh)unclassified

“…S1) 1 (17,50,54). Obwohl die IRH meist gutartig verläuft, besteht langfristig das Risiko einer Anämie, eines Eisenmangels und einer obstruktiven Uropathie (17,94).…”

Section: Idiopathische Renale Hämaturie (Irh)unclassified

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Minimal-invasive interventionelle Verfahren am Urogenitaltrakt von Hund und Katze

Heilmann¹

2016

Tierarztl Prax Ausg K

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“…Tissue plasminogen activator (tPA) is a serine protease utilized in human and veterinary medicine as a fibrinolytic . Endogenous mammalian tPA, predominantly produced by vascular endothelium, is a critical component in clot dissolution via conversion of plasminogen into plasmin, which breaks down fibrin .…”

Section: Introductionmentioning

confidence: 99%

“…Tissue plasminogen activator (tPA) is a serine protease utilized in human and veterinary medicine as a fibrinolytic. [1][2][3][4][5][6] Endogenous mammalian tPA, predominantly produced by vascular endothelium, is a critical component in clot dissolution via conversion of plasminogen into plasmin, which breaks down fibrin. 7 Recombinant biotechnology has produced several tPA variants, originally intended for intravenous use during acute treatment of myocardial infarction in people.…”

Section: Introductionmentioning

confidence: 99%

Effect of immediate postoperative intracameral tissue plasminogen activator (tPA) on anterior chamber fibrin formation in dogs undergoing phacoemulsification

Mancuso

Nadelstein

Berdoulay

et al. 2019

Veterinary Ophthalmology

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Objective To evaluate the postoperative effect of intracameral tPA (alteplase; Activase®, Genentech, San Francisco, CA), administered at immediate conclusion of phacoemulsification, on anterior chamber fibrin formation in dogs. Procedures Forty‐one dogs (82 eyes) undergoing bilateral phacoemulsification received 25 μg/0.1 mL intracameral tPA in one eye and 0.1 mL unmedicated aqueous vehicle in the contralateral eye immediately after corneal incision closure. Intraocular pressure (IOP) was measured, and severity of anterior chamber fibrin formation, aqueous flare, pigment precipitates on the intraocular lens (IOL) implant, posterior capsular opacification (PCO), and corneal edema were graded at approximately 1 week, 2‐3 weeks, 4‐6 weeks, 8‐12 weeks, and greater than 3 months postoperatively. Results Anterior chamber fibrin developed postoperatively in 68.3% of dogs (28/41) and 50% of eyes (41/82). In tPA‐treated eyes, 53.7% (22/41) developed fibrin compared to 46.3% of control eyes (19/41). Some degree of postoperative ocular hypertension (POH) occurred in 53.7% of dogs (22/41) and 36.5% of eyes (30/82). In tPA‐treated eyes, 34.1% (14/41) experienced POH compared to 39% of control eyes (16/41). Additional intracameral tPA injection was later required in 29.3% of both tPA‐treated (12/41) and control eyes (12/41). Conclusions Administration of intracameral tPA at immediate conclusion of canine phacoemulsification had no clinically observable effect on anterior chamber fibrin incidence at any time point. tPA‐treated eyes showed no prophylaxis against POH or secondary glaucoma compared to control eyes and received late postoperative tPA injections at the same frequency as control eyes.

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Administration of Other Biological Products

Prittie¹,

Stefano²

2023

Advanced Monitoring and Procedures for Small Animal Emergency and Critical Care

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Dissolution of Urinary Bladder Clots in a Dog with Alteplase

Cited by 5 publications

References 6 publications

Minimal-invasive interventionelle Verfahren am Urogenitaltrakt von Hund und Katze

Minimal-invasive interventionelle Verfahren am Urogenitaltrakt von Hund und Katze

Effect of immediate postoperative intracameral tissue plasminogen activator (tPA) on anterior chamber fibrin formation in dogs undergoing phacoemulsification

Administration of Other Biological Products

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