Dissolution and regeneration of collagen fibers using ionic liquid

Meng, Zhuojun; Zheng, Xuejing; Tang, Keyong; Liu, Jie; Ma, Zhi; Zhao, Qiaoling

doi:10.1016/j.ijbiomac.2012.05.030

Cited by 107 publications

(67 citation statements)

References 27 publications

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“…The spectra of pADM and OHTCC‐pADM treated with different amounts of OHTCC are shown in Figure . It has already been reported that the amide I band at approximately 1650 cm −1 is mainly attributed to the contraction vibration of the CO bond present in the collagen molecule. The amide II band located in the vicinity at 1540 cm −1 could be attributed to the synergistic effect of the bending vibration of NH and the telescopic vibration of CN.…”

Section: Resultsmentioning

confidence: 97%

Functional chemical modification of a porcine acellular dermal matrix with a modified naturally derived polysaccharide crosslinker

Dan

Huang

Bai

et al. 2019

J of Applied Polymer Sci

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Antibacterial and physicochemical properties are generally considered important features of the porcine acellular dermal matrix (pADM). Oxidized 2-hydroxypropyltrimethyl ammonium chloride chitosan (OHTCC) was applied to crosslink with pADM at dosages of 1, 2, 4, 8, and 16%. The properties of the crosslinked pADM (OHTCC-pADM) were evaluated. DSC and TG analysis suggested that crosslinking could promote the thermal stability, the highest T d , and T max of OHTCC-pADM (8%) was 80 C and 325 C, which has been improved by 15 C and 13 C, respectively. While FTIR and AFM tests indicated that the structure integrity of collagen could still be maintained. SEM tests demonstrated the sustained three-dimensional architecture of OHTCC-pADM with appropriate porosity. Moreover, OHTCC-pADM exhibited improved ability to resist collagenase degradation, the degradation rate of 4%-, 8%-OHTCC-pADM was <50%. The tensile strength of OHTCC-pADM proved to be superior compared to pADM. Furthermore, 8%-OHTCC-pADM exhibited nearly 90% antibacterial activity against Escherichia coli, and Staphylococcus aureus. In addition, the results of the 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazoliumbromide study showed that the cytocompatibility of OHTCC-pADM decreased with the increasing the amount of OHTCC, but all relative proliferation rates were above 80%. In conclusion, our study revealed that OHTCC stabilized and functionalized pADM while preserving good cytocompatibility.

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Section: Resultsmentioning

confidence: 97%

Functional chemical modification of a porcine acellular dermal matrix with a modified naturally derived polysaccharide crosslinker

Dan

Huang

Bai

et al. 2019

J of Applied Polymer Sci

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“…). Hence, amide I was present at 1656 and 1159 cm – amide II was observed at 1539 cm −1 , amide III at 1452 and 1244 cm – amide A at 3468 cm −136, and amide B at 2968 cm −1 . Other functional groups (CH 3 , CH 2 , CH) may have contributed to absorption at 1339 cm −142 (Fig.…”

Section: Resultsmentioning

confidence: 94%

“…4). The interaction between BC crystals and WJ, probably containing some amino acid residues of the poly-peptide chains, could be attributed to the phosphate band between 980 and 1150 cm 21 , [34][35][36][37][38][39][40][41][42] whereas the 878 cm 21 could be attributed to the carbonation of HA, which closely resembles that of natural bone tissue 43 (Fig. 4).…”

Section: Structural Mechanical and Biochemical Characterizationmentioning

confidence: 99%

Synthesis and characterization of a novel scaffold for bone tissue engineering based on Wharton's jelly

Martinez

Fernández

Prado

et al. 2017

J Biomedical Materials Res

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A composite is a material made of more than one component, and the bond between the components is on a scale larger than the atomic scale. The objective of the present study was to synthesize and perform the structural characterization and biological evaluation of a new biocomposite (BCO) based on a novel combination of an organic and an inorganic phase, for bone tissue engineering applications. The organic phase consisted of Wharton's jelly (WJ), which was obtained from embryonic tissue following a protocol developed by our laboratory. The inorganic phase consisted of bioceramic particles (BC), produced by sintering hydroxyapatite (HA) with β- tricalcium phosphate (β-TCP), and bioactive glass particles (BG). Each phase of the BCO was fully characterized by SEM, EDS, XRD, and FTIR. Biocompatibility was evaluated in vivo in the tibiae of Wistar rats (n = 40). Histological evaluation was performed at 0, 1, 7, 14, 30, and 60 days. XRD showed the phases corresponding to HA and β-TCP, whereas diffractogram of BG showed it to have an amorphous structure. EDS showed mainly Si and Na, Ca, P in BG, and Ca and P in HA and β-TCP. FTIR identified bonds between the organic and inorganic phases. From a mechanical viewpoint, the composite showed high flexural strength of 40.3 ± 0.8 MPa. The synthesized BCO exhibited adequate biocompatibility as shown by formation of lamellar type bone linked by BG and BC particles. The biomaterial presented here showed excellent mechanical and biocompatibility properties for its potential clinical use. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1034-1045, 2017.

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“…15 1-Butyl-3-methylimidazolium chloride (Bmim Cl) has been reported to aid in dissolution of various insoluble biopolymers, [16][17][18] including collagen from the skin matrix at higher temperatures. 19 However, at the molecular level, imidazolium ILs do not affect the conformation of collagen at room temperature. 20 The current focus of research is to employ IL in the preparation of biomaterials for tuning properties of biomacromolecules.…”

Section: Introductionmentioning

confidence: 98%

Microenvironmental changes in collagen/polyvinyl alcohol blends in the presence of ionic liquid: A spectroscopic analysis

Mehta

Kanungo

Rao

et al. 2015

Journal of Bioactive and Compatible Polymers

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This study describes the microenvironmental changes due to various non-covalent interactions occurring in collagen/polyvinyl alcohol blends in the presence of ionic liquid, 1-butyl-3-methylimidazolium chloride, using spectroscopic techniques. These non-covalent interactions alter the hydration network of collagen. Electronic spectral analysis of collagen/polyvinyl alcohol/ionic liquid blends exhibited movement of tyrosine amino acid from the hydrophilic to hydrophobic core of collagen. Conformational studies investigating the influence of 1-butyl-3-methylimidazolium chloride on the intramolecular H-bonds revealed increased helicity packing and reorientation of H-bonds. This signifies that 1-butyl-3-methylimidazolium chloride is likely to be involved in reorienting the hydration dynamics of collagen, namely, by altering the existing and promoting formation of new intramolecular H-bonds between collagen and polyvinyl alcohol. Surface morphology of collagen/polyvinyl alcohol/ionic liquid blends revealed porous matrix, indicating 1-butyl-3-methylimidazolium chloride could act as a pore generator. This phenomenon can be employed for developing novel biomaterials with tunable porosity.

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Dissolution and regeneration of collagen fibers using ionic liquid

Cited by 107 publications

References 27 publications

Functional chemical modification of a porcine acellular dermal matrix with a modified naturally derived polysaccharide crosslinker

Functional chemical modification of a porcine acellular dermal matrix with a modified naturally derived polysaccharide crosslinker

Synthesis and characterization of a novel scaffold for bone tissue engineering based on Wharton's jelly

Microenvironmental changes in collagen/polyvinyl alcohol blends in the presence of ionic liquid: A spectroscopic analysis

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