2016
DOI: 10.18632/aging.101069
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Abstract: Despite regulation, brain iron increases with aging and may enhance aging processes including neuroinflammation. Increases in magnetic resonance imaging transverse relaxation rates, R2 and R2*, in the brain have been observed during aging. We show R2 and R2* correlate well with iron content via direct correlation to semi-quantitative synchrotron-based X-ray fluorescence iron mapping, with age-associated R2 and R2* increases reflecting iron accumulation. Iron accumulation was concomitant with increased ferritin… Show more

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Cited by 24 publications
(20 citation statements)
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References 90 publications
(119 reference statements)
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“…Consistent with previous reports including our own (Walker et al, 2016), iron was present at higher concentrations in the substantia nigra and globus pallidus compared to that in the striatum, cortex, and hippocampus at the older ages (Hallgren and Sourander, 1958). The iron levels increased with age predominantly in the basal ganglia, suggesting iron to be an age-dependent enriched metal in the brain (Connor et al, 1990).…”
Section: Ironsupporting
confidence: 91%
“…Indeed, increased ferritin mirrors the iron deposition in the globus pallidus and striatum we observed. However, a dissociation between iron accumulation and ferritin upregulation was observed in the aged substantia nigra, where higher levels of iron were not associated with increased levels of ferritin as we and others have reported previously (Benkovic and Connor, 1993;Walker et al, 2016). Ferritin is composed of 24 subunits of two types, heavy and light chains, forming a soluble hollow shell capable of storing up to 4,500 ferric iron atoms (Harrison and Arosio, 1996).…”
Section: Ironmentioning
confidence: 48%
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