Dissemination of an Extended-Spectrum-β-Lactamase
 bla
 TEM-52
 Gene-Carrying IncI1 Plasmid in Various
 Salmonella enterica
 Serovars Isolated from Poultry and Humans in Belgium and France between 2001 and 2005

Cloeckaert, Axel; Praud, Karine; Doublet, Benoît; Bertini, Alessia; Carattoli, Alessandra; Butaye, Patrick; Imberechts, Hein; Bertrand, Sophie; Collard, Jean-Marc; Arlet, Guillaume; Weill, François‐Xavier

doi:10.1128/aac.01514-06

Cited by 115 publications

(116 citation statements)

References 15 publications

(21 reference statements)

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“…Further successful spread of ESBL and AmpC genes occurs by different lateral genetic transfer processes involving insertion sequences, transposons, Class 1 integrons and overall, the transferable plasmids in which they are located (Arduino et al, 2002;Eckert et al, 2006;Girlich et al, 2011;Oliver et al, 2005;Poirel et al, 2008;Toleman et al, 2006). Among animal isolates, studies focused on these genetic features have shown that, overall, these mobile elements were the same as those identified in human isolates (Carattoli, 2009;Cloeckaert et al, 2007;Leverstein-van Hall et al, 2011). This observation has reinforced some of the hypotheses suggestive of direct links between the two bacterial populations.…”

Section: Integronssupporting

confidence: 57%

“…Particular clones of S. Infantis seem to be widespread among poultry in some EU countries, for example, in France and Belgium as well Japan (Cloeckaert et al, 2007;Dahshan et al, 2010;Yang et al, 2010). A recent report has also described this serovar among pigs (Dahshan et al, 2010).…”

Section: Salmonellamentioning

confidence: 98%

“…By far the most common genes associated with this resistance have been those encoding CTX-M enzymes (the most commonly identified ESBL), followed by bla TEM-52 and bla SHV-12 (Bortolaia et al, 2010b;Chiaretto et al, 2008;Cloeckaert et al, 2007;Escudero et al, 2010;Hasman et al, 2005;Jensen et al, 2006;Machado et al, 2008;Randall et al, 2011;Smet et al, 2008). The ESBL enzymes associated with animals correspond to CTX-M (-1, -2, -3, -8, -9, -14, -15, -17/18, -20, -32, -55), TEM and SHV (SHV-2, -5 and -12).…”

Section: Esbl And/or Ampc Encoding Resistance Genesmentioning

confidence: 99%

“…Among Salmonella, global spread of multi-drug resistant (MDR) (to chloramphenicol, florfenicol, streptomycin, spectinomycin, sulphonamides, tetracyclines and trimethoprim) clones belonging to serovars Agona with SGI-1 (Salmonella Genomic Island 1)-A, or Typhimurium of definitive phage type (DT) 104 carrying SGI-1 have been linked to TEM-52 production (Cloeckaert et al, 2007). Particular clones of S. Infantis seem to be widespread among poultry in some EU countries, for example, in France and Belgium as well Japan (Cloeckaert et al, 2007;Dahshan et al, 2010;Yang et al, 2010).…”

Section: Salmonellamentioning

confidence: 99%

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Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

2011

EFSA Journal

240

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The potential contribution of food-producing animals or foods to public health risks by ESBL and/or AmpCproducing bacteria is related to specific plasmid-mediated ESBL and/or AmpC genes encoded by a number of organisms. The predominant ESBL families encountered are CTX-M, TEM, and SHV; the predominant AmpCfamily is CMY. The most common genes associated with this resistance in animals are bla CTX-M-1 (the most commonly identified ESBL), and bla CTX-M-14 , followed by bla and bla Among the genes encoding AmpC-type β-lactamases, bla CMY-2 is the most common.The bacterial species most commonly identified with these genes are Escherichia coli and non-typhoidal Salmonella. ESBL/AmpC transmission is mainly driven by integrons, insertion sequences, transposons and plasmids, some of which are homologous in isolates from both food-production animals and humans. Cefotaxime is used as the drug of choice for optimum detection of bla ESBL and/or bla AmpC genes. The preferred method for isolation of ESBL-and/or AmpC-producers is screening on selective agar preceded by selective enrichment in a broth.The establishment of risk factors for occurrence of ESBL/AmpC-producing bacteria is particularly complicated by the data unavailability or lack of its accuracy. The use of antimicrobials is a risk factor for the selection and spread of resistant clones, resistance genes and plasmids. Since most ESBL-and AmpC-producing strains carry additional resistances to other commonly-used veterinary drugs, generic antimicrobial use is a risk factor for ESBL/AmpC and it is not restricted specifically to the use of cephalosporins. An additional risk factor is extensive trade of animals in EU MS. There are no data on the comparative efficiency of individual control options in reducing public health risks caused by ESBL and/or AmpC-producing bacteria related to food-producing animals. Prioritisation is complex, but it is considered that a highly effective control option would be to stop all uses of cephalosporins/systemically active 3 rd /4 th generation cephalosporins, or to restrict their use (use only allowed under specific circumstances). As co-resistance is an important issue, it is also of high priority to decrease the total antimicrobial use in animal production in the EU. KEY WORDSResistance, ESBLs, AmpC, occurrence, transmission, control options, public health microbiology. SUMMARYFollowing a request from the European Commission, the Panel on Biological Hazards (BIOHAZ) was asked to deliver a Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum beta (β)-lactamases (ESBL) and/or AmpC β-lactamases (AmpC) in food and foodproducing animals. In particular, the Panel was asked: (i) to propose a definition of the ESBL-and/or AmpC-producing bacterial strains and genes relevant for public health and linked to food-producing animals or food borne transmission; (ii) to review the information on the epidemiology of acquired resistance to broad spectrum cephalosporins including the genes coding for ...

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Section: Integronssupporting

confidence: 57%

Section: Salmonellamentioning

confidence: 98%

Section: Esbl And/or Ampc Encoding Resistance Genesmentioning

confidence: 99%

Section: Salmonellamentioning

confidence: 99%

See 2 more Smart Citations

Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

2011

EFSA Journal

240

View full text Add to dashboard Cite

show abstract

“…A similar spread was demonstrated for cephalosporinresistant S. Infantis. In this case, ESBL resistance was located on a conjugative plasmid that had already spread to some other serotypes, including Java and Typhimurium (Bertrand, S et al, 2006;Cloeckaert, A et al, 2007).…”

Section: Comparison Between Those Prevalences; Their Significancementioning

confidence: 99%

Joint Opinion on antimicrobial resistance (AMR) focused on zoonotic infections

2009

EFSA Journal

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Prevalence of Extended Spectrum Beta Lactamase (ESBL)-Producing E. coli: A Systematic Overview

Vijayan

Sivaraman

Bachmann

2023

Handbook on Antimicrobial Resistance

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Dissemination of an Extended-Spectrum-β-Lactamase bla _TEM-52 Gene-Carrying IncI1 Plasmid in Various Salmonella enterica Serovars Isolated from Poultry and Humans in Belgium and France between 2001 and 2005

Cited by 115 publications

References 15 publications

Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

Joint Opinion on antimicrobial resistance (AMR) focused on zoonotic infections

Prevalence of Extended Spectrum Beta Lactamase (ESBL)-Producing E. coli: A Systematic Overview

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Dissemination of an Extended-Spectrum-β-Lactamase bla TEM-52 Gene-Carrying IncI1 Plasmid in Various Salmonella enterica Serovars Isolated from Poultry and Humans in Belgium and France between 2001 and 2005

Cited by 115 publications

References 15 publications

Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

Joint Opinion on antimicrobial resistance (AMR) focused on zoonotic infections

Prevalence of Extended Spectrum Beta Lactamase (ESBL)-Producing E. coli: A Systematic Overview

Contact Info

Product

Resources

About

Dissemination of an Extended-Spectrum-β-Lactamase bla _TEM-52 Gene-Carrying IncI1 Plasmid in Various Salmonella enterica Serovars Isolated from Poultry and Humans in Belgium and France between 2001 and 2005