Disseminated Parainfluenza Infection in a Child With Severe Combined Immunodeficiency

Pulmonary diseases in children with severe combined immune deficiency and DiGeorge syndrome

“…The high mortality rate of parainfluenza infection in patients with SCID has been described. 23,24 In our study parainfluenza was detected as a cause of respiratory illness in only two children. However, both children are alive after successful bone marrow transplantation.…”

Pulmonary diseases in children with severe combined immune deficiency and DiGeorge syndrome

“…The high mortality rate of parainfluenza infection in patients with SCID has been described. 23,24 In our study parainfluenza was detected as a cause of respiratory illness in only two children. However, both children are alive after successful bone marrow transplantation.…”

Parainfluenza 3 Respiratory Infection Associated with Pericardial Effusion in a Very Low Birthweight Infant

“…Parainfluenza 3 was isolated in respiratory secretions and pericardial and cerebrospinal fluids. Postmortem evaluation confirmed the presence of the pathogen in the lung, brain, and pericardial samples [1]. The second case is a 9-year-old immunocompetent patient with pericardial effusion in whom parainfluenza 4 was isolated in nasopharyngeal aspirate.…”

A robust mouse model of human parainfluenza 3 virus infection and efficacy of GS-441524, the parent nucleoside of remdesivir, against lung pathology

“…Thus, ribavirin is certainly not an ideal drug for the treatment of infections by HPIVs. Severe HPIV infections may develop in the elderly and patients with underlying chronic conditions and may even be fatal in immunocompromised patients, in particular in recipients of a hematopoietic stem cell transplant and in children with severe combined immunodeficiency disease syndrome 37,50,51,53,54 . Since remdesivir has been approved for the treatment of SARS-CoV-2 infection and is safe and well tolerated, we propose that it (or obeldesivir) should be considered for the treatment of HPIV infections.…”

Pulmonary diseases in children with severe combined immune deficiency and DiGeorge syndrome

“…The high mortality rate of parainfluenza infection in patients with SCID has been described. 23,24 In our study parainfluenza was detected as a cause of respiratory illness in only two children. However, both children are alive after successful bone marrow transplantation.…”

Parainfluenza 3 Respiratory Infection Associated with Pericardial Effusion in a Very Low Birthweight Infant

“…Parainfluenza 3 was isolated in respiratory secretions and pericardial and cerebrospinal fluids. Postmortem evaluation confirmed the presence of the pathogen in the lung, brain, and pericardial samples [1]. The second case is a 9-year-old immunocompetent patient with pericardial effusion in whom parainfluenza 4 was isolated in nasopharyngeal aspirate.…”

A robust mouse model of human parainfluenza 3 virus infection and efficacy of GS-441524, the parent nucleoside of remdesivir, against lung pathology

“…Thus, ribavirin is certainly not an ideal drug for the treatment of infections by HPIVs. Severe HPIV infections may develop in the elderly and patients with underlying chronic conditions and may even be fatal in immunocompromised patients, in particular in recipients of a hematopoietic stem cell transplant and in children with severe combined immunodeficiency disease syndrome 37,50,51,53,54 . Since remdesivir has been approved for the treatment of SARS-CoV-2 infection and is safe and well tolerated, we propose that it (or obeldesivir) should be considered for the treatment of HPIV infections.…”

Pulmonary diseases in children with severe combined immune deficiency and DiGeorge syndrome

“…The high mortality rate of parainfluenza infection in patients with SCID has been described. 23,24 In our study parainfluenza was detected as a cause of respiratory illness in only two children. However, both children are alive after successful bone marrow transplantation.…”

Parainfluenza 3 Respiratory Infection Associated with Pericardial Effusion in a Very Low Birthweight Infant

“…Parainfluenza 3 was isolated in respiratory secretions and pericardial and cerebrospinal fluids. Postmortem evaluation confirmed the presence of the pathogen in the lung, brain, and pericardial samples [1]. The second case is a 9-year-old immunocompetent patient with pericardial effusion in whom parainfluenza 4 was isolated in nasopharyngeal aspirate.…”

A robust mouse model of human parainfluenza 3 virus infection and efficacy of GS-441524, the parent nucleoside of remdesivir, against lung pathology

“…Thus, ribavirin is certainly not an ideal drug for the treatment of infections by HPIVs. Severe HPIV infections may develop in the elderly and patients with underlying chronic conditions and may even be fatal in immunocompromised patients, in particular in recipients of a hematopoietic stem cell transplant and in children with severe combined immunodeficiency disease syndrome 37,50,51,53,54 . Since remdesivir has been approved for the treatment of SARS-CoV-2 infection and is safe and well tolerated, we propose that it (or obeldesivir) should be considered for the treatment of HPIV infections.…”