Abstract:An 11-year-old boy had a relapse of acute lymphoblastic leukemia involving the CNS. He was treated with whole brain radiotherapy and intrathecal methotrexate. One week after the whole brain radiotherapy, he developed personality changes and right facial weakness. Brain MRI was obtained (Figure 1). Disseminated necrotizing leukoencephalopathy is an uncommon neurotoxicity syndrome associated with whole brain radiotherapy and methotrexate. Personality change is commonly reported 1. Disseminated necrotizing leukoe… Show more
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