Disseminated hyalohyphomycosis in a leukemic patient

Matsuda, T.

doi:10.1001/archderm.122.10.1171

Cited by 22 publications

(10 citation statements)

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“…Other moulds including Pseudallescheria boydii and Fusarium sp can resemble Aspergillus and be indistinguishable histologically. [29][30][31][32] In our study, two cases with hyphael forms consistent with Aspergillus sp, in cytology specimens grew Candida sp in culture. Rarely, Candida sp can produce true hyphae with septation which appears similar to Aspergillus.…”

Section: Discussionmentioning

confidence: 51%

Aspergillus in cytology specimens: A review of 45 specimens from 36 patients

et al. 1997

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Objective To assess the clinical significance associated with the identification of fungal elements consistent with Aspergillus in cytology specimens. Materials and Methods For all cytology specimens with reported fungal elements consistent with Aspergillus, reported over a 9 yr and 8 mo period at The Cleveland Clinic Foundation, the patient's medical charts were reviewed with particular attention to underlying disease, presentation, treatment, and clinical course. Cytology results were compared with available microbiologic cultures and tissue specimens in all of the patients. Results Forty‐five cytology specimens with Aspergillus fungal forms, from 36 patients, were identified. Twenty‐six patients had concurrent specimens sent for culture in whom 11 grew Aspergillus species (10 Aspergillus fumigatus), eight grew organisms other than Aspergillus, and seven were no growth. A total of 16 patients (44%) were treated with antifungal treatment (Amphotericin B). Treatment with Amphotericin B was significantly associated with a concurrent growth of Aspergillus species (9/11 patients with Aspergillus culture positive vs. 7/25 patients without a positive culture for Aspergillus, P value = 0.004 (ODDS ratio = 11, 95% confidence interval: #1.6–104.2‐tailed Fisher exact test.) Conclusions The presence of fungal forms consistent with Aspergillus in cytology specimens is neither specific nor sensitive for significant infection due to Aspergillus. Treatment with Amphotericin B is more likely to be instituted when a concurrent clinical specimen grows Aspergillus species in culture. Diagn. Cytopathol. 16:26–30, 1997. © 1997 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 51%

Aspergillus in cytology specimens: A review of 45 specimens from 36 patients

et al. 1997

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“…The term "hyalohyphomycosis" has been used for opportunistic mycotic infection caused by nondematiaceous molds whose basic tissue forms usually consists of septate, branched, or unbranched hyphae forms (1,2). Fusarium is a fungal group that includes approximately 200 species that are rapid growers in Sabouraud's agar or on fungal media without cyclohexamide (3,4).…”

Section: Discussionmentioning

confidence: 99%

“…The lungs, sinuses, and kidneys are the viscera most commonly involved with disseminated disease. Myalgias are a frequent complaint with disseminated infection (1,10,11,19,23). On biopsy sections from lesional specimens stained with periodic acid-Schiff or Grocott stains, Fusarium resembles other fungal organisms with branching septate hyphae, particularly Aspergillus, Acremonium, and Penicillium, and shows a propensity for vascular wall invasion, similar to Aspergillus and Mucor (3)(4)(5)7,8,15).…”

Section: Discussionmentioning

confidence: 99%

“…The increasitig use of long-term intravascular catheters in immunocompromised patients is one possible explanation for the more frequent occurrence of Fusarium infections and for the ease of isolating the species from the blood (3,5,9,24). The fatal outcome of most patients probably relates to the underlying severe immunosuppression and neutropenia, which play an important role in defense against fungal infections (1,3,5,11,16,25). The majority of disseminated infections have occurred in patients with acute leukemia who are undergoing chemotherapy or bone marrow transplantation, and in those with extensive bums.…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous Fusarium Infection in an Adolescent with Acute Leukemia

Alvarez-Franco

Reyes‐Múgica

Paller

1992

Pediatric Dermatology

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Disseminated fusariosis occurred in a pediatric patient with acute lymphocytic leukemia in relapse. The patient had fever and neutropenia, and scattered violaceous papules and vesicles with central erosions that rapidly progressed to generalized, painful, violaceous, papulovesicular lesions with central necrosis. Severe myalgias were associated. The diagnosis was suspected by noting hyphae on a smear of vesicular contents, and confirmed by culture. The clinical course was rapidly fatal despite early institution of amphotericin B therapy. Disseminated Fusarium infection should be suspected in immunocompromised patients with fever and neutropenia who have generalized, eroded, violaceous papules, vesicles, and pustules, particularly with associated myalgias.

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“…Primary cutaneous hyalohyphomycosis and phaeohyphomycosis have been reported to present clinically in many ways. These include asymptomatic nodules and cysts (2,13), verrucous plaques (5), multiple nodules (7), and crusted erythematous nodules studded with pustules (4). In healthy individuals, the most common presentation is that of a nontender, firm or fluctuant subcutaneous nodule (2).…”

Section: Discussionmentioning

confidence: 99%

Hyalohyphomycosis masquerading as squamous cell carcinoma

Griffin

McFarland

1991

J Cutan Pathol

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A case of primary cutaneous hyalohyphomycosis in a healthy individual is presented. The initial clinical impression was keratoacanthoma or squamous cell carcinoma. Upon excision, the lesion proved to be an example of cutaneous hyalohyphomycosis due to an unidentified, non-pigmented fungal organism. The lesion was completely excised, and the patient was treated with saturated solution of potassium iodide. To date, there has been no evidence of recurrence. The clinical, histologic and mycologic aspects of hyalophyphomycosis are discussed.

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Disseminated hyalohyphomycosis in a leukemic patient

Cited by 22 publications

References 0 publications

Aspergillus in cytology specimens: A review of 45 specimens from 36 patients

Aspergillus in cytology specimens: A review of 45 specimens from 36 patients

Cutaneous Fusarium Infection in an Adolescent with Acute Leukemia

Hyalohyphomycosis masquerading as squamous cell carcinoma

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