Disseminated granuloma annulare treated with low-dose chlorambucil

Rudolph, R. I.

doi:10.1001/archderm.115.10.1212

Cited by 7 publications

(1 citation statement)

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“…Nevertheless, some of these treatments have concerning side effect profiles. Chlorambucil, for instance, has been reported in the management of GA [ 6 ] yet it is a very risky treatment as it can precipitate hemorrhagic cystitis. Similarly, dapsone was recently reported to be used for the treatment of GA in 26 patients, and while 54% of patients experienced improvement, 31% of patients experienced myelosuppression, which required treatment to be discontinued [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Apremilast in the Management of Disseminated Granuloma Annulare

Joshi¹,

Tschen²

2021

Cureus

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Granuloma annulare (GA) is a common inflammatory skin condition that manifests as annular skin colored to erythematous papules and plaques. Disseminated GA is a subtype of GA that presents with diffuse cutaneous involvement. While topical and intralesional corticosteroids and phototherapy have been used as therapies for GA, there is no consensus on the best course of treatment for GA. Apremilast is a phosphodiesterase 4 (PDE4) inhibitor that has been Food and Drug Administration (FDA) approved for psoriasis, psoriatic arthritis, and oral ulcers associated with Behcet’s disease; apremilast has also shown promise off-label for other inflammatory skin conditions. Here, we present the case of a woman in whom apremilast use led to an almost complete resolution of her disseminated GA. Our patient tolerated apremilast well and reported no side effects. We also review the literature on the use of apremilast in other patients with GA.

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Section: Discussionmentioning

confidence: 99%