Disseminated Disease by Mycobacterium abscessus and Mycobacterium celatum in an Immunocompromised Host

Locatelli, Maria Elena; Tosto, Salvatore; D’Agata, Vincenzo; Bonaventura, Paolo; Grasso, Rosaria; Marino, Andrea; Pampaloni, Alessio; Scuderi, Daniele; Cosentino, Federica; Cacopardo, Bruno

doi:10.12659/ajcr.921517

Cited by 7 publications

(3 citation statements)

References 16 publications

(15 reference statements)

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“…Studies on M. abscessus osteomyelitis are even rarer. This pathogen is characterized as life-threatening in the geriatric community and among individuals with AIDS [ 3 , 12 ]. M. abscessus can also infect immunocompetent individuals.…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium abscessus Complex Osteomyelitis of the Wrist

Alter¹,

Trenschel²,

Schwartz³

et al. 2022

Cureus

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Mycobacterium abscessus (M. abscessus) is a ubiquitous, rapidly growing non-tuberculous mycobacterium, which is known to cause life-threatening lung infections in immunocompromised individuals following exposure to contaminated injectable products. We report a case of M. abscessus osteomyelitis of the right wrist in a 28-year-old patient with a history of intravenous drug use and a recent surgical repair of the right radial artery pseudoaneurysm. The patient underwent surgical debridement of the right distal radius infection. Histopathological examination and culture of the debrided tissue revealed M. abscessus complex infection. The patient was placed on intravenous amikacin, azithromycin, and cefoxitin for six weeks, followed by oral linezolid and clofazimine for six months.

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Section: Discussionmentioning

confidence: 99%

Mycobacterium abscessus Complex Osteomyelitis of the Wrist

Alter¹,

Trenschel²,

Schwartz³

et al. 2022

Cureus

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“…On the other hand, non-tuberculous mycobacteria (NTM) diseases significantly affect patients with HIV, particularly those with advanced immunodeficiency, due to their severe symptoms and complex treatment requirements (6,7). Despite advancements being made in antiretroviral therapy, NTM diseases remain a major cause of morbidity (8).…”

Section: Introductionmentioning

confidence: 99%

Rare case of Rhodococcus hoagii bacteremia in an HIV late‑presenter with NTM pulmonary disease: A case report and review of the literature

Pulvirenti,

Marino,

Stracquadanio

et al. 2024

World Acad Sci J

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“…Mycobacterium abscessus (MAB) is the rapidly growing nontuberculous mycobacteria that ubiquitously exist in the environment and has been isolated from drinking water, household showerheads, hospital wastewater, and plumbing in large quantities [1]. MAB is an opportunistic pathogen of clinical importance because it can infect and colonize the bronchial airways of patients with cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), or bronchiectasis [2] as well as cause disseminated infections in immunocompromised and postsurgical patients [3,4]. Incidents of MAB pulmonary infections have been increasing in recent years [5], causing fatality in 15% of patients [6,7].…”

Section: Introductionmentioning

confidence: 99%

Understanding the Phage–Host Interaction Mechanism toward Improving the Efficacy of Current Antibiotics in Mycobacterium abscessus

Gorzynski,

De Ville,

Week

et al. 2023

Biomedicines

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Pulmonary infections caused by Mycobacterium abscessus (MAB) have been increasing in incidence in recent years, leading to chronic and many times fatal infections due to MAB’s natural resistance to most available antimicrobials. The use of bacteriophages (phages) in clinics is emerging as a novel treatment strategy to save the lives of patients suffering from drug-resistant, chronic, and disseminated infections. The substantial research indicates that phage–antibiotic combination therapy can display synergy and be clinically more effective than phage therapy alone. However, there is limited knowledge in the understanding of the molecular mechanisms in phage–mycobacteria interaction and the synergism of phage–antibiotic combinations. We generated the lytic mycobacteriophage library and studied phage specificity and the host range in MAB clinical isolates and characterized the phage’s ability to lyse the pathogen under various environmental and mammalian host stress conditions. Our results indicate that phage lytic efficiency is altered by environmental conditions, especially in conditions of biofilm and intracellular states of MAB. By utilizing the MAB gene knockout mutants of the MAB_0937c/MmpL10 drug efflux pump and MAB_0939/pks polyketide synthase enzyme, we discovered the surface glycolipid diacyltrehalose/polyacyltrehalose (DAT/PAT) as one of the major primary phage receptors in mycobacteria. We also established a set of phages that alter the MmpL10 multidrug efflux pump function in MAB through an evolutionary trade-off mechanism. The combination of these phages with antibiotics significantly decreases the number of viable bacteria when compared to phage or antibiotic-alone treatments. This study deepens our understanding of phage–mycobacteria interaction mechanisms and identifies therapeutic phages that can lower bacterial fitness by impairing an antibiotic efflux function and attenuating the MAB intrinsic resistance mechanism via targeted therapy.

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Disseminated Disease by Mycobacterium abscessus and Mycobacterium celatum in an Immunocompromised Host

Cited by 7 publications

References 16 publications

Mycobacterium abscessus Complex Osteomyelitis of the Wrist

Mycobacterium abscessus Complex Osteomyelitis of the Wrist

Rare case of Rhodococcus hoagii bacteremia in an HIV late‑presenter with NTM pulmonary disease: A case report and review of the literature

Understanding the Phage–Host Interaction Mechanism toward Improving the Efficacy of Current Antibiotics in Mycobacterium abscessus

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