Disseminated Cryptococcosis Due to Anti-Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in the Absence of Pulmonary Alveolar Proteinosis

Kuo, Chang‐Fu; Wang, Shang‐Yu; Shih, Han-Po; Tu, Kun Hua; Huang, Wei-Chen; Ding, Jing-Ya; Lin, Chia Hao; Yeh, Chun Fu; Ho, Mao Wang; Chang, Shi Chuan; He, Chi Ying; Chen, Hung-Kai; Ho, Chen Hsuan; Lee, Chen Hsiang; Yu, Chih Teng; Ku, Cheng

doi:10.1007/s10875-016-0364-4

Cited by 52 publications

(36 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is no consensus on the best therapeutic approach for patients with GM‐CSF antibody associated cryptococcosis. Variable response rates have been reported with standard antifungal therapy . This variation may be due to anti‐GM‐CSF antibody titres, serotypes, residual GM‐CSF activity, sites of infection, and other host factors.…”

Section: Discussionmentioning

confidence: 99%

“…1 GM-CSF is a pro-inflammatory cytokine which enhances granulocyte priming and survival in tissues, and stimulates alveolar macrophages to clear surfactant. 2 GM-CSF antibodies were initially reported in oncology patients receiving recombinant GM-CSF therapy, and in a subset of thymoma and myasthenia gravis patients. 3,4 However, in most cases these antibodies were non-neutralising and unlikely to be functionally significant.…”

Section: Discussionmentioning

confidence: 99%

“…Variable response rates have been reported with standard antifungal therapy. 2,13 This variation may be due to anti-GM-CSF antibody titres, serotypes, residual GM-CSF activity, sites of infection, and other host factors. Plasmapheresis and/or B cell depleting therapy may be considered in cases refractory to antifungal therapy.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The significance of anti‐granulocyte‐macrophage colony‐stimulating factor antibodies in cryptococcal infection: case series and review of antibody testing

Stevenson

Bundell

Mulrennan

et al. 2019

Internal Medicine Journal

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The significance of anti‐granulocyte‐macrophage colony‐stimulating factor antibodies in cryptococcal infection: case series and review of antibody testing

Stevenson

Bundell

Mulrennan

et al. 2019

Internal Medicine Journal

View full text Add to dashboard Cite

show abstract

“…In Asian population including Thai patients, anti-IFN-Ƴ autoantibodies have associated with disseminated infection secondary to several opportunistic organisms, such as nontuberculous mycobacteria, Salmonella non-Typhi, Varizella-zoster virus and fungi [ 18 ]. In addition, high level of anti-GM-CSF autoantibodies was associated with cryptococcal meningitis [ 19 , 20 ] and disseminated cryptococcosis [ 21 ] in HIV-negative patients who had no previously apparent immunodeficiencies. The present case had negative results of the both autoantibodies.…”

Section: Discussionmentioning

confidence: 99%

Undiagnosed Cryptococcus gattii meningitis leading to subsequent ventriculoperitoneal shunt infection in a patient with symptoms of normal pressure hydrocephalus: case report and literature review

2018

View full text Add to dashboard Cite

BackgroundCryptococcus gattii is known to be an etiologic agent of human cryptococcosis, particularly in immunocompetent persons. C. gattii infection usually involves the central nervous system, the respiratory tract, or may be disseminated. Here we report an atypical manifestation of C. gattii infection in a patient who had C. gattii meningitis complicating the ventriculoperitoneal (VP) shunt infection and concurrent infected intraabdominal VP shunt pseudocyst.Case presentationA 66-year-old Thai female was initially diagnosed with normal pressure hydrocephalus (NPH) and underwent programmable VP shunt placement. However, she still suffered from recurrent communicating hydrocephalus with in-place VP shunt, and later developed recurrent gait impairment, chronic abdominal pain and abdominal mass. Radiological studies demonstrated recurrent hydrocephalus and a very large intraabdominal VP shunt pseudocyst. C. gattii was isolated from both the cerebrospinal fluid and the pseudocyst aspiration. C. gattii meningitis complicating the VP shunt infection and concurrent infected intraabdominal VP shunt pseudocyst was diagnosed. Prolonged antifungal therapy, removal of the infected VP shunt with subsequent implant of a new shunt provided a good outcome.ConclusionChronic C. gattii meningitis should be aware in a patient presenting with normal pressure hydrocephalus. Under-diagnosed cryptococcal meningitis following VP shunt insertion for treating the hydrocephalus can render a complicated VP shunt infection including infected VP shunt pseudocyst.

show abstract

“…In several cases, patients with anti‐granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) autoantibodies developed into severe cryptococcosis . These cases indicate the important role of GM‐CSF in defending against Cryptococcus infection.…”

Section: Adjunctive Therapymentioning

confidence: 99%

Management of human immunodeficiency virus–associated cryptococcal meningitis: Current status and future directions

Shen

2019

Mycoses

View full text Add to dashboard Cite

Summary Cryptococcal meningitis (CM) is one of the most common opportunistic infections of acquired immunodeficiency syndrome (AIDS), as well as an important cause of hospitalisation and death. In recent years, the mortality of CM has remained high in HIV/AIDS population, with up to 30%, including within developed countries. The treatment usually encompasses controls of Cryptococcus, HIV, and increased intracranial pressure. Recent progress on the management of HIV‐associated CM mainly centres in optimising induction regimens, looking for appropriate timing of initiating antiretroviral therapy and prevention of symptomatic onset and adverse consequences. This review compared several international guidelines combined with the results from some clinical researches to illustrate the similarities, differences and potential in CM treatment. The present practice is still far from satisfactory, and there remains much to explore due to our limited understanding of the pathogenesis of HIV‐associated CM. Thus, screening and monitoring should be strengthened, and better therapies in line with the actual situation of each country should be discovered.

show abstract

Disseminated Cryptococcosis Due to Anti-Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in the Absence of Pulmonary Alveolar Proteinosis

Cited by 52 publications

References 30 publications

The significance of anti‐granulocyte‐macrophage colony‐stimulating factor antibodies in cryptococcal infection: case series and review of antibody testing

The significance of anti‐granulocyte‐macrophage colony‐stimulating factor antibodies in cryptococcal infection: case series and review of antibody testing

Undiagnosed Cryptococcus gattii meningitis leading to subsequent ventriculoperitoneal shunt infection in a patient with symptoms of normal pressure hydrocephalus: case report and literature review

Management of human immunodeficiency virus–associated cryptococcal meningitis: Current status and future directions

Contact Info

Product

Resources

About