Disseminated Anergic American Leishmaniasis

Convit, J

doi:10.1001/archderm.1957.01550200057012

Cited by 19 publications

(7 citation statements)

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“…DCL is characterized by a single painless nodule that eventually progresses to multiple papulonodules, macules and infiltrative plaques covering much of the body; 6,44 sensation is unaffected 36 . An initial plaque or macule may also be noted.…”

Section: Discussionmentioning

confidence: 99%

“…Extension to the mucocutaneous junction can occur, although mucosal surfaces are, for the most part, unaffected 45 . The lesions may be flesh‐colored or range from slightly erythematous to violaceous in color 44 . The parasite load in these lesions is enormous.…”

Section: Discussionmentioning

confidence: 99%

“…Lymphatic spread of the parasites creates lesions with sporotrichoid morphology 49,50 . Other terms used to describe the lesions reflect the varieties of distribution and mimicry of other conditions: chromoblastomycoid, pyodermoid, syphiloid, and epitheliomatoid 44 . Secondary infection of lesions 48,51 and a chronic course with failure to respond to therapy are common.…”

Section: Discussionmentioning

confidence: 99%

“…45 The lesions may be flesh-colored or range from slightly erythematous to violaceous in color. 44 The parasite load in these lesions is enormous. Areas most commonly affected include the face, upper and lower extremities, and buttocks.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…49,50 Other terms used to describe the lesions reflect the varieties of distribution and mimicry of other conditions: chromoblastomycoid, pyodermoid, syphiloid, and epitheliomatoid. 44 Secondary infection of lesions 48,51 and a chronic course with failure to respond to therapy are common. Spontaneous resolution of some of the lesions can occur, although this is atypical.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

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Diffuse cutaneous leishmaniasis associated with the immune reconstitution inflammatory syndrome

et al. 2008

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Leishmaniasis is an emerging disease in HIV-infected persons; visceral leishmaniasis is an AIDS-defining opportunistic infection. The parasite that causes this infection is usually transmitted by the sandfly and occasionally by nonsterile needles among intravenous drug users. Diffuse cutaneous leishmaniasis (DCL) is a rare anergic variant of leishmanial infection with the characteristic presentation of numerous nonulcerating nodules with an abundant parasite load, lack of visceral involvement, negative reaction to the leishmanin skin test, and a chronic course with incomplete response to treatment and frequent relapses. We report a case of DCL that developed in the context of the immune reconstitution inflammatory syndrome (IRIS) in a man with AIDS following initiation of antiretroviral therapy. We also review DCL to emphasize the importance of recognizing and treating this evolving disease in the growing population of patients on immunorestorative therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%