“…Systemic involvement of elastic tissue had been reported in idiopathic EPS (London et al 1974, Pedro & Garcia 1974, Eide 1977, although possible reactive forms have to be differentiated (London et al 1974), To our knowledge, involvement of pulmonary elastic tissue with cyst formation induced by penicillamine has not been reported previously and will form the subject of a separate report. We should like to re-emphasize, however, that widespread cutaneous involvement in penicillamine-treated patients may only represent the cutaneous expression of a systemic phenomenon also involving other structures, such as visceral organs, as well as medium and large-sized vessles (Texier et al 1974).…”