Dissecting the Molecular Basis of Host Leucine-Rich Repeat Containing 15 Mediated Interaction with Receptor Binding Domain of SARS-CoV-2 Spike Protein: A Computational Approach
Sarbani Mishra,
Mansi Sharma,
Mahendra Kumar Singh
et al.
Abstract:The
detection of leucine-rich repeat containing 15 (LRRC15) as
a connecting link with severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) underscores the possibility of its involvement in differential
restriction activity of SARS-CoV-2 pathways. However, the structure–function
mechanism of LRRC15 involving the receptor binding domain (RBD) of
the SARS-CoV-2 spike protein and their mode of interaction is largely
unknown. Using state-of-the-art AlphaFold2 and all-atom molecular
dynamics simulations, our… Show more
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