Disruption of Graft Endothelium Correlates With Early Failure After Off-Pump Coronary Artery Bypass Surgery

Manchio, Jeffrey V.; Gu, Jun; Romar, Linda; Brown, James M.; Gammie, James S.; Pierson, Richard N.; Griffith, Bartley P.; Poston, Robert

doi:10.1016/j.athoracsur.2004.12.054

Cited by 61 publications

(67 citation statements)

References 32 publications

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“…However, the authors emphasize the practical limitations of the original, labor-intensive TEG methodology, which may indicate why many past studies included small sample sizes -often 100 patients or fewer, and sometimes as few as ten patients [15]. Larger studies often examined only patients undergoing a specific operation [16,17]. Only one large prospective study has examined the use of TEG in the prediction of thromboembolic events in general surgery [12] and found promising results that require further investigation.…”

Section: Discussionmentioning

confidence: 99%

Rotational thromboelastometry predicts thromboembolic complications after major non-cardiac surgery

et al. 2014

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Introduction: Thromboembolic complications contribute substantially to perioperative morbidity and mortality. Routine laboratory tests do not detect patients with acquired or congenital hypercoagulability who may be at increased risk of perioperative thromboembolism. Rotational thromboelastometry (ROTEM) is a digitized modification of conventional thromboelastography that is stable and technically easy to use. We designed a prospective observational study to evaluate whether preoperative ROTEM can identify patients at increased risk for postoperative thromboembolic complications after major non-cardiac surgery. Methods: Preoperative ROTEM analysis using extrinsic rotational thromboelastometry (EXTEM), intrinsic rotational thromboelastometry (INTEM), and fibrinogen rotational thromboelastometry (FIBTEM) activators was performed on 313 patients undergoing major non-cardiac surgery. Patients' medical records were reviewed after discharge for results of standard coagulation studies -partial thromboplastin time (PTT), international normalized ratio (INR), platelet count -and evidence of thromboembolic complications during their hospital stay. A thromboembolic complication was defined as a new arterial or deep venous thrombosis, catheter thrombosis, or pulmonary embolism diagnosed by ultrasound or spiral chest computed tomography.

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Section: Discussionmentioning

confidence: 99%

Rotational thromboelastometry predicts thromboembolic complications after major non-cardiac surgery

et al. 2014

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“…Mechanical trauma has been shown to increase neointimal hyperplasia in human saphenous vein organ cultures and high pressure distension was found to destroy large parts of the endothelium [4,5]. Manchio et al found an association between the degree of endothelial denudation and early SVG failure in OPCAB [6].…”

Section: Surgical Handling Of Svgsmentioning

confidence: 98%

The role of vein grafts in coronary surgery

2007

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“…24 Recruitment of circulating progenitor cells to sites of injury is central to the repair process. 2 IGF-1 is recognized to increase the circulating abundance and enhance the function of endothelial progenitor cells via a mechanism involving phosphoinositide-3-kinase/Aktmediated phosphorylation of eNOS.…”

Section: Discussionmentioning

confidence: 99%

Haploinsufficiency of the Insulin-Like Growth Factor-1 Receptor Enhances Endothelial Repair and Favorably Modifies Angiogenic Progenitor Cell Phenotype

Yuldasheva

Rashid

Haywood

et al. 2014

ATVB

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Objectives— Defective endothelial regeneration predisposes to adverse arterial remodeling and is thought to contribute to cardiovascular disease in type 2 diabetes mellitus. We recently demonstrated that the type 1 insulin-like growth factor receptor (IGF1R) is a negative regulator of insulin sensitivity and nitric oxide bioavailability. In this report, we examined partial deletion of the IGF1R as a potential strategy to enhance endothelial repair. Approach and Results— We assessed endothelial regeneration after wire injury in mice and abundance and function of angiogenic progenitor cells in mice with haploinsufficiency of the IGF1R (IGF1R +/− ). Endothelial regeneration after arterial injury was accelerated in IGF1R +/− mice. Although the yield of angiogenic progenitor cells was lower in IGF1R +/− mice, these angiogenic progenitor cells displayed enhanced adhesion, increased secretion of insulin-like growth factor-1, and enhanced angiogenic capacity. To examine the relevance of IGF1R manipulation to cell-based therapy, we transfused IGF1R +/− bone marrow–derived CD117 + cells into wild-type mice. IGF1R +/− cells accelerated endothelial regeneration after arterial injury compared with wild-type cells and did not alter atherosclerotic lesion formation. Conclusions— Haploinsufficiency of the IGF1R is associated with accelerated endothelial regeneration in vivo and enhanced tube forming and adhesive potential of angiogenic progenitor cells in vitro. Partial deletion of IGF1R in transfused bone marrow–derived CD117 + cells enhanced their capacity to promote endothelial regeneration without altering atherosclerosis. Our data suggest that manipulation of the IGF1R could be exploited as novel therapeutic approach to enhance repair of the arterial wall after injury.

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Disruption of Graft Endothelium Correlates With Early Failure After Off-Pump Coronary Artery Bypass Surgery

Cited by 61 publications

References 32 publications

Rotational thromboelastometry predicts thromboembolic complications after major non-cardiac surgery

Rotational thromboelastometry predicts thromboembolic complications after major non-cardiac surgery

The role of vein grafts in coronary surgery

Haploinsufficiency of the Insulin-Like Growth Factor-1 Receptor Enhances Endothelial Repair and Favorably Modifies Angiogenic Progenitor Cell Phenotype

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