Disrupted melatonin-secretion during alcohol withdrawal

Assessment of the cellular integrity and expression of melatonin receptor (MTNR1A) in the retina assaulted by ethanol and acetaminophen

“…Ethanol exposure induces oxidative stress damage to different tissues in the body; however, various studies have shown that melatonin may be useful to prevent oxidative stress reactions due to its antioxidant properties. 12 This finding corroborates the existing work of Schmitz et al 25 who concluded that alcoholism can cause a sharp decrease or complete cessation of Melatonin synthesis and a single dose of alcohol can induce changes in the circadian rhythm of an organism. Taking together our findings, it can be inferred that chronic simultaneous intake/ consumption of alcohol and acetaminophen altered the melatonin level in the retina and this may implicate the circadian clock and melatonin in Wistar rat visual system.…”

Assessment of the cellular integrity and expression of melatonin receptor (MTNR1A) in the retina assaulted by ethanol and acetaminophen

“…Ethanol exposure induces oxidative stress damage to different tissues in the body; however, various studies have shown that melatonin may be useful to prevent oxidative stress reactions due to its antioxidant properties. 12 This finding corroborates the existing work of Schmitz et al 25 who concluded that alcoholism can cause a sharp decrease or complete cessation of Melatonin synthesis and a single dose of alcohol can induce changes in the circadian rhythm of an organism. Taking together our findings, it can be inferred that chronic simultaneous intake/ consumption of alcohol and acetaminophen altered the melatonin level in the retina and this may implicate the circadian clock and melatonin in Wistar rat visual system.…”

A Functional Polymorphism in the Promoter Region of the Tryptophan Hydroxylase Gene Is Associated With Alcohol Dependence in One Aboriginal Group in Taiwan

“…Alcohol consumption impairs the central circadian pacemaker via altering the period genes (per1, per2, per3) expressions (Chen et al, 2004). Alcoholic patients showed higher urine melatonin levels than healthy subjects and disturbed diurnal changes of melatonin levels (Murialdo et al, 1991;Schmitz et al, 1996). Findings in this study may suggest that individuals with higher TPH1 gene activities may show higher amplitude of melatonin rhythm and, consequently, be more prone to withdrawal symptoms (e.g., insomnia) of alcohol dependence.…”

Reduced Expression of Circadian Clock Genes in Male Alcoholic Patients

“…Furthermore, the effects are remarkable during AW and may last over a substantial period of abstinence (Brower, 2001;Imatoh et al, 1986;Kodama et al, 1988;Mukai et al, 1998;Sano et al, 1993;Schmitz et al, 1996). It may explain the persistent alterations of circadian rhythm gene expressions in our patients after 1 week of detoxification.…”

Assessment of the cellular integrity and expression of melatonin receptor (MTNR1A) in the retina assaulted by ethanol and acetaminophen

“…Ethanol exposure induces oxidative stress damage to different tissues in the body; however, various studies have shown that melatonin may be useful to prevent oxidative stress reactions due to its antioxidant properties. 12 This finding corroborates the existing work of Schmitz et al 25 who concluded that alcoholism can cause a sharp decrease or complete cessation of Melatonin synthesis and a single dose of alcohol can induce changes in the circadian rhythm of an organism. Taking together our findings, it can be inferred that chronic simultaneous intake/ consumption of alcohol and acetaminophen altered the melatonin level in the retina and this may implicate the circadian clock and melatonin in Wistar rat visual system.…”

A Functional Polymorphism in the Promoter Region of the Tryptophan Hydroxylase Gene Is Associated With Alcohol Dependence in One Aboriginal Group in Taiwan

“…Alcohol consumption impairs the central circadian pacemaker via altering the period genes (per1, per2, per3) expressions (Chen et al, 2004). Alcoholic patients showed higher urine melatonin levels than healthy subjects and disturbed diurnal changes of melatonin levels (Murialdo et al, 1991;Schmitz et al, 1996). Findings in this study may suggest that individuals with higher TPH1 gene activities may show higher amplitude of melatonin rhythm and, consequently, be more prone to withdrawal symptoms (e.g., insomnia) of alcohol dependence.…”

Reduced Expression of Circadian Clock Genes in Male Alcoholic Patients

“…Furthermore, the effects are remarkable during AW and may last over a substantial period of abstinence (Brower, 2001;Imatoh et al, 1986;Kodama et al, 1988;Mukai et al, 1998;Sano et al, 1993;Schmitz et al, 1996). It may explain the persistent alterations of circadian rhythm gene expressions in our patients after 1 week of detoxification.…”

Assessment of the cellular integrity and expression of melatonin receptor (MTNR1A) in the retina assaulted by ethanol and acetaminophen

“…Ethanol exposure induces oxidative stress damage to different tissues in the body; however, various studies have shown that melatonin may be useful to prevent oxidative stress reactions due to its antioxidant properties. 12 This finding corroborates the existing work of Schmitz et al 25 who concluded that alcoholism can cause a sharp decrease or complete cessation of Melatonin synthesis and a single dose of alcohol can induce changes in the circadian rhythm of an organism. Taking together our findings, it can be inferred that chronic simultaneous intake/ consumption of alcohol and acetaminophen altered the melatonin level in the retina and this may implicate the circadian clock and melatonin in Wistar rat visual system.…”

A Functional Polymorphism in the Promoter Region of the Tryptophan Hydroxylase Gene Is Associated With Alcohol Dependence in One Aboriginal Group in Taiwan

“…Alcohol consumption impairs the central circadian pacemaker via altering the period genes (per1, per2, per3) expressions (Chen et al, 2004). Alcoholic patients showed higher urine melatonin levels than healthy subjects and disturbed diurnal changes of melatonin levels (Murialdo et al, 1991;Schmitz et al, 1996). Findings in this study may suggest that individuals with higher TPH1 gene activities may show higher amplitude of melatonin rhythm and, consequently, be more prone to withdrawal symptoms (e.g., insomnia) of alcohol dependence.…”

Reduced Expression of Circadian Clock Genes in Male Alcoholic Patients

“…Furthermore, the effects are remarkable during AW and may last over a substantial period of abstinence (Brower, 2001;Imatoh et al, 1986;Kodama et al, 1988;Mukai et al, 1998;Sano et al, 1993;Schmitz et al, 1996). It may explain the persistent alterations of circadian rhythm gene expressions in our patients after 1 week of detoxification.…”