Disposition of nifedipine in plasma and gingival crevicular fluid in relation to drug‐induced gingival overgrowth

Ellis, J. S.; Seymour, R. A.; Monkman, S. C.; Idle, J R

doi:10.1111/j.1600-0765.1993.tb01081.x

Cited by 31 publications

(21 citation statements)

References 21 publications

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“…10,15 The results of the present study are in agreement with studies which have reported that the concentration of nifedipine in GCF does not relate to gingival overgrowth degree. 10,15 Similar to the results of this study, Thomason et al 15 could not determine a relationship between GCF and plasma drug concentrations in 63 organ transplant patients. However, in contrast to the present findings, a statistically significant relationship between GCF and plasma nifedipine concentration has been reported.…”

Section: Discussionsupporting

confidence: 92%

“…9 It has been shown that several drugs like nifedipine, amlodipine, phenytoin, tetracycline and ciprofloxacin can be detected in GCF. [10][11][12][13][14] The relationship between the pharmacokinetic variables of nifedipine with the incidence and severity of gingival enlargement has been investigated in nine adult males. 10 The results of this study suggested that there was no relationship between plasma/GCF nifedipine concentration and the degree of gingival overgrowth.…”

Section: Introductionmentioning

confidence: 99%

“…[10][11][12][13][14] The relationship between the pharmacokinetic variables of nifedipine with the incidence and severity of gingival enlargement has been investigated in nine adult males. 10 The results of this study suggested that there was no relationship between plasma/GCF nifedipine concentration and the degree of gingival overgrowth. Moreover, high levels of nifedipine sequestered in the GCF were also detected in 63 organ transplant patients.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and pharmacological variables as a risk factor for nifedipine‐induced gingival overgrowth

Güncü¹,

Çağlayan²,

Dinçel³

et al. 2007

Australian Dental Journal

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Background: Gingival enlargement is usually noted within one to two months after the initiation of nifedipine therapy. The aetiology of nifedipineinduced gingival overgrowth is uncertain. The aim of this study was to determine the relationship between plasma and gingival crevice fluid (GCF) nifedipine concentrations and the degree of gingival overgrowth in patients treated with nifedipine, and also to assess the correlations between clinical and pharmacological variables. Methods: Eighteen patients taking nifedipine in regular doses for at least six months participated in the study. Gingival enlargement was evaluated with two indices to score vertical and horizontal overgrowth. Gingival index (GI), plaque index (PI), gingival bleeding time index (GBTI), probing depth (PD) and clinical attachment level (CAL) were also evaluated.GCF and plasma nifedipine concentrations were determined by using high performance liquid chromatography. Results: There was no significant difference between responders and non-responders for PI, GI and GBTI. The mean concentration of nifedipine in GCF was significantly greater than concentration in plasma. No significant difference was observed for GCF and plasma nifedipine concentration between responders and non-responders. Conclusions: The present study showed that neither GCF nor plasma nifedipine levels appeared to be a risk factor for nifedipine-induced gingival overgrowth. Improving the oral hygiene in patients using nifedipine may help control the degree of druginduced gingival enlargement.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical and pharmacological variables as a risk factor for nifedipine‐induced gingival overgrowth

Güncü¹,

Çağlayan²,

Dinçel³

et al. 2007

Australian Dental Journal

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“…66 It has been reported in one study that nifedipine concentrates in the gingival crevicular fluid up to 90 times the serum concentration and, of the nine patients examined, nifedipine could be found in the crevicular fluid of all five of the patients with gi n gi va l overgrowth and two of the 'non-responders'. 67 While a male predominance has been reported 68 it should be remembered that most studies in this area have not been randomized.The variability of the clinical appearance of this gingival overgrowth is probably related to the level of oral hygiene (Fig. 3b-3d).…”

Section: Gingival Overgrowth Nifedipinementioning

confidence: 99%

A clinical review of drug‐induced gingival overgrowths

Marshall

Bartold

1999

Australian Dental Journal

126

139

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There is an increasing number of medications associated with gingival overgrowth. These medications are used to treat a number of common conditions in the Australian population and as such dentists can expect to manage a number of patients with medication-related gingival overgrowth. This review highlights the clinical features and management of the common overgrowths associated with anticonvulsants, immunosuppressants and the calcium channel blockers.

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“…IL-1α predominates (16) in gingival crevicular fluid and a greater amount of nifedipine is found in gingival crevicular fluid in the patients with periodontal disease (19,20). The aim of this study was thus to investigate the simultaneous effect of nifedipine and IL-1α on cell proliferation and DNA synthesis of gingival fibroblasts from nifedipine responders and non-responders.…”

Section: Introductionmentioning

confidence: 99%

The effect of IL-l.ALPHA. and nifedipine of cell proliferation and DNA synthesis in cultured human gingival fibroblasts

et al. 2005

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The effect of nifedipine and interleukin-α (IL-1α) on the cell proliferation and DNA synthesis was studied in human gingival fibroblasts derived from 5 patients who developed gingival overgrowth (nifedipine responders) and 5 patients who did not develop gingival overgrowth (nifedipine non-responders) in response to nifedipine. Epidermal growth factor was used as a positive control. The fibroblasts derived from nifedipine responders tended to have a numerically greater rate of cell proliferation and DNA synthesis ( 3 H-thymidine incorporation) than those from nifedipine nonresponders in the presence of nifedipine and IL-1α. Fibroblasts derived from nifedipine responders showed significantly higher cell proliferation rate in the presence of nifedipine and IL-1α, than nifedipine or IL-1α alone on both the second and the fourth day of incubation (P < 0.05). A combination of IL-1α and epidermal growth factor also showed significantly greater cell proliferation than IL-1α alone on the second day (P < 0.05). The DNA synthesis rate with a combination of nifedipine and IL-1α was higher than that for nifedipine alone on the second day (P < 0.01), and IL-1α alone on the fourth day (P < 0.05) in gingival fibroblasts originating from nifedipine responders. These results suggest that the interaction between nifedipine and gingival inflammation might play an important role in the pathogenesis of nifedipine-induced gingival overgrowth. (J. Oral Sci. 47, [105][106][107][108][109][110] 2005)

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Disposition of nifedipine in plasma and gingival crevicular fluid in relation to drug‐induced gingival overgrowth

Cited by 31 publications

References 21 publications

Clinical and pharmacological variables as a risk factor for nifedipine‐induced gingival overgrowth

Clinical and pharmacological variables as a risk factor for nifedipine‐induced gingival overgrowth

A clinical review of drug‐induced gingival overgrowths

The effect of IL-l.ALPHA. and nifedipine of cell proliferation and DNA synthesis in cultured human gingival fibroblasts

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