Disorders of hemostatic function in patients with systemic lupus erythematosus

The lupus coagulation inhibitor and venous thrombosis: a report of four cases

“…The four patients we describe had major venous thrombosis associated with the circulating anticoagulant which is observed most commonly in SLE and only rarely in its absence (Lee & Miotti 1975). Two of our cases (J.T.…”

“…Demonstration of the inhibitor has questionable clinical implications since it seldom causes haemorrhage when it is an isolated finding (Feinstein & Rapaport 1972). Paradoxically, it may be associated with a susceptibility to venous thrombosis, a feature which has not been emphasized in some recent reviews (Lee & Miotti 1975, Boxer, Ellman & Carvalho 1976. We describe four patients in whom recurrent or extensive venous thrombosis was associated with the presence of the lupus coagulation in hi bi tor.…”

Migraine and the Lupus Anticoagulant: Case Reports and Review of the Literature

“…There is evidence that platelets are activated in association with a migraine attack (35)(36)(37). Antiphospholipid antibodies can activate platelets by binding to platelet membrane phospholipids (22,34), including phosphatidylserine, phosphatidylcholine, and sphingomyelin, thereby altering platelet function (38)(39)(40). There is some evidence that the functional platelet abnormalities found in migraineurs are associated with abnormalities in platelet plasma membrane lipid composition, changing membrane dynamics (41,42).…”

Disseminated Intravascular Coagulation in a Patient with Systemic Lupus Erythematosus with Lupus Anticoagulant.

“…However, the levels of fibrinogen and AT III are usually observed within the normal range or are slightly elevated in patients with TMA.Therefore, we diagnosed that she had DICbased on the fact that her clinical manifestations and laboratory findings fulfilled the criteria for DIC. Hematological abnormalities in SLE may be due to autoimmunemanifestations, such as circulating anticoagulants, CICs or vasculitis (1,(13)(14)(15). Although the development ofDIC in SLE is an unusual clinical event, ithas been suggested that an activation of the coagulation system to somedegree occurs in the majority of the patients with active SLE (16).…”