Disorderly CD44 gene expression in human cancer cells can be modulated by growth conditions

Sugino, Takashi; Yoshida, Kazuhiro; Zhao, Shenru; Goodison, Steven; Tarin, David

doi:10.1002/(sici)1096-9896(199809)186:1<17::aid-path138>3.0.co;2-a

Cited by 11 publications

(6 citation statements)

References 14 publications

(11 reference statements)

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“…We have also observed an accentuated staining pattern of CD44 IR observed in reactive (45) and highly proliferative urothelium, associated with previous therapy (45). Sugino et al (46) reported that overexpression of CD44 is observed in the initial stages of bladder and other cancers.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Cytokeratin 20 and CD44 Protein Expression with WHO/ISUP Grade in pTa and pT1 Papillary Urothelial Neoplasia

et al. 2000

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The aim of this study was to assess the relationship of immunoreactivity of cytokeratin 20 (CK20) and CD44 across the spectrum of urothelial neoplasia using the WHO/ISUP consensus classification. A total of 120 papillary urothelial pTa and pT1 tumors (8 papillomas, 8 neoplasms of low malignant potential, and 42 low-grade and 62 high-grade carcinomas) were immunostained by using CK20 and CD44 antibodies. The relationships of tumor grade, pathologic stage, recurrences, and progression in stage with CK20 and CD44 immunoreactivity were assessed. WHO/ISUP grade correlated with tumor stage (P < 0.005), recurrence (P ‫؍‬ 0.02), and progression in stage (P ‫؍‬ 0.031). Normal urothelium showed CK20 immunoreactivity restricted to a few umbrella cells. Expression of CD44 in normal urothelium was restricted to the basal cell layer. Loss of CD44 immunoreactivity and increasing CK20 positivity were significantly associated with increasing tumor grade and stage (P < 0.005). An inverse relationship was observed in the staining patterns of CK20 and CD44 within individual cases, as well as in the aggregate data, with 79.2% of tumors with CD44 loss showing CK20 positivity (P < 0.001). In conclusion, CK20 and CD44 immunoreactivity are significantly related to the WHO/ISUP grade and to each other, and our data suggest their potential combined utility in predicting biologic behavior in patients with papillary urothelial pTa and pT1 neoplasms.

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Section: Discussionmentioning

confidence: 99%

Relationship of Cytokeratin 20 and CD44 Protein Expression with WHO/ISUP Grade in pTa and pT1 Papillary Urothelial Neoplasia

et al. 2000

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“…Accordingly, expression patterns may change as the invading neoplastic cells encounter different mesenchymal components in the microenvironment. 23 In uterine cervical cancer, loss of expression of CD44v6 was also noticed in advanced invasive tumors. 24 However, we could not find any relation between extensive CD44v6 staining in marginal tumor cells and the depth of invasion.…”

Section: Commentmentioning

confidence: 99%

Prognostic Value of CD44 Variant 6 in Laryngeal Epidermoid Carcinomas

Güler

Saraç²,

Üner³

et al. 2002

Arch Otolaryngol Head Neck Surg

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“…This suggests that although the expression of CD44 is disorderly in tumor cells, the regulation of CD44 transcription is not beyond the influence of the extracellular environment. This has recently been confirmed in studies using tumor cell lines cultured under various growth conditions (99).…”

Section: Summary Of Cd44 In Neoplasiamentioning

confidence: 58%