Disoprofol Anaesthesia in Horses – A Preliminary Report

Propofol compared with propofoVguaiphenesin after detornidine premedication for equine surgery

“…The reduction in heart rate observed in both groups was similar to that described by Nolan and Chambers (1989) and was probably a result of the a,-agonist effect of detomidine (Clarke and Taylor 1986). When xylazine, a shorter acting a,-agonist was used, slight tachycardia was observed after induction (Nolan andHall 1985, Taylor 1989). Hypotension is also a common finding after the use of propofol in horses (Nolan andHall 1985, Taylor 1989).…”

“…When xylazine, a shorter acting a,-agonist was used, slight tachycardia was observed after induction (Nolan andHall 1985, Taylor 1989). Hypotension is also a common finding after the use of propofol in horses (Nolan andHall 1985, Taylor 1989). Despite the statistical difference, in this study heart rate ranged from 45 to 53 beats/minute during anaesthesia, representing values which are normal for horses.…”

“…Propofol has been used for induction and maintenance of anaesthesia in horses, providing safe, short term anaes-thesia with rapid and uneventful recovery even when used as a continuous infusion (Nolan 1982, Nolan and Hall 1985, Nolan and Chambers 1989, Taylor 1989.…”

“…The usual recommended dose for induction of anaesthesia in premedicated horses is 2 mg/kg (Nolan 1982, Nolan and Hall 1985, Nolan and Chambers 1989, Taylor 1989) and, in spite of the advantages of propofol, the high cost limits its use in horses. Combination of propofol with other drugs might be a useful means of decreasing the dose and consequently the cost of the drug.…”

Equine anaesthesia: Discovery and rediscovery

“…With this agent onset of anaesthesia, following intravenous injection, is rapid and there is an apparent lack of accumulation in the body so that recovery occurs very soon after its administration is stopped. Pilot studies in horses (Nolan 1982) have proved promising and a continued assessment of disoprofol as an agent for total intravenous anaesthesia appears to be indicated.…”