Disodium etidronate therapy for dystrophic cutaneous calcification

Rabens, S. F.

doi:10.1001/archderm.111.3.357

Cited by 11 publications

(7 citation statements)

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“…The authors suggested that this probably represented an inadequate compensatory response of osteoprotegerin as an inhibitor of calcification [25]. Two case reports showed successful use of bisphosphonates for the treatment of calcinosis in SSc patients suggesting that impaired bone metabolism may play a role in the pathogenesis of calcinosis [26,27]. Notably, we found that SSc patients with calcinosis had a lower rate of steroid usage than those without calcinosis, yet have a higher frequency of osteoporosis.…”

Section: Discussionmentioning

confidence: 64%

Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium study

Valenzuela

Baron

Herrick

et al. 2016

Seminars in Arthritis and Rheumatism

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Objectives We sought to identify the clinical factors associated with calcinosis in an international multicenter collaborative effort with the Scleroderma Clinical Trials Consortium (SCTC). Methods This is a retrospective cohort study of 5218 patients with systemic sclerosis (SSc). Logistic regression was used to obtain odds ratios (OR) relating calcinosis to various clinical features in multivariate analyses. Results A total of 1290 patients (24.7%) had calcinosis. In univariate analyses, patients with calcinosis were older than patients without calcinosis, more likely to be female, and had longer disease duration from the first non-Raynaud phenomenon symptom. Patients with calcinosis were more likely to have digital ulcers, telangiectasias, acro-osteolysis, cardiac disease, pulmonary hypertension, gastrointestinal involvement, arthritis, and osteoporosis, but less likely to have muscle disease. Anti-Scl-70, RNA-polymerase-III, and U1-RNP autoantibodies were significantly less common in patients with calcinosis, while anticentromere (ACA), anti-PM/Scl, and anticardiolipin antibodies were more frequent. In multivariate analysis, the strongest associations with calcinosis were digital ulcers (OR = 3.9; 95% CI: 2.7–5.5; p < 0.0001) and osteoporosis (OR = 4.2; 95% CI: 2.3–7.9; p < 0.0001). Conclusion One quarter of patients with SSc have calcinosis at some time during their illness. Our data confirm a strong association of calcinosis with digital ulcers, and support a novel association with osteoporosis.

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Section: Discussionmentioning

confidence: 64%

Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium study

Valenzuela

Baron

Herrick

et al. 2016

Seminars in Arthritis and Rheumatism

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“…However, treatment may result in osteomalacia and pathological fractures, and exacerbation of disease has been noted on treatment withdrawal. 7 A Vitamin K-dependent amino-acid, gamma-carboxyglutamic acid, has been found to act at calcium ion binding sites in bones and soft tissues. 8 Raised urinary levels have been demonstrated in patients with calcinosis and connective tissue disorders.…”

Section: Injection Of Marcainmentioning

confidence: 99%

Parotid calcification in systemic lupus erythematosis

2002

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“…The pharmacological treatment of calcinosis cutis is difficult and includes bisphosphonates, intralesional corticosteroids, aluminum hydroxide, warfarin, diltiazem, minocycline, ceftriaxone, intravenous immunoglobulin/EDTA, probenecid, and colchicine [25,26,27,28,29]. Topical therapy with sodium thiosulfate 100% powder mixed in ratio 1:4 (25%) in zinc oxide applied under occlusion with elastic wraps is another option.…”

Section: Discussionmentioning

confidence: 99%

Milia-like idiopathic calcinosis cutis in a child with Down syndrome

Kumar¹,

Savant²,

Nimisha³

et al. 2016

DOJ

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Idiopathic calcinosis cutis refers to progressive deposition of crystals of calcium phosphate in the skin and other areas of the body, in the absence of any inciting factor. Idiopathic calcinosis cutis may sometimes take the form of small, milia-like lesions. Most commonly, such milia like lesions are seen in the setting of Down syndrome. Herein, we report a 5-year-old girl with multiple asymptomatic discrete milia-like firm papules distributed over the face and extremities. A diagnosis of milia-like idiopathic calcinosis cutis associated with Down Syndrome was provisionally made and was confirmed by histopathology and karyotyping.

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Disodium etidronate therapy for dystrophic cutaneous calcification

Cited by 11 publications

References 0 publications

Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium study

Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium study

Parotid calcification in systemic lupus erythematosis

Milia-like idiopathic calcinosis cutis in a child with Down syndrome

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