Dislipidemia associada à doença renal crônica – Revisão de literatura

Marques, Franciane Santos; Silva, Alysson Luiz Mendes da; Couto, Ricardo David

doi:10.9771/cmbio.v13i2.12444

Cited by 1 publication

(2 citation statements)

References 36 publications

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“…Pacientes com DRC apresentam um risco aumentado de desenvolver doenças vasculares que se manifestam com calcificação por distintas patologias 19,22 . Estudos sugerem que certas situações clínicas como a hipóxia, promovam e acelerem a calcificação vascular 18,23,24 , fortemente associada ao processo de remodelagem endotelial e alterações no metabolismo de cálcio, como consequência da DRC 25 .…”

Section: Aspectos Fisiopatológicosunclassified

“…Na disfunção do metabolismo de lipoproteínas, ainda que o paciente apresente um colesterol dentro dos valores de referência, esta expressa a tríade aterogênica: hipertrigliceridemia, aumento sérico do colesterol da lipoproteína de muito baixa densidade (VLDL-C) e redução do colesterol das lipoproteínas de alta densidade (HDL-C) 25 . Embora representem uma porção relativamente pequena da matriz orgânica, os lipídios são parte integrante de tecidos mineralizados e desempenham um papel significativo no processo de calcificação, promovendo a nucleação do cristal, bem como sendo incorporados às calcificações em crescimento 26 .…”

Section: Aspectos Fisiopatológicosunclassified

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Renal hypoxia, vascular calcification and crystalline nephropathy

Gomes¹

2022

Rev Pat Tocantins

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ABSTRACT Objective: To emphasize the increase, in the last decades, in the incidence of kidney diseases and associated comorbidities and, within a wide range of kidney injury triggers, it is important to mention the nephropathies caused by crystal and mineral deposition, considering the often slow, gradual and asymptomatic progression of these disorders. Methods: This is a literature review based on the search for articles related to the topics ‘Crystalluria and renal hypoxia’, in databases such as Pubmed, Bireme, Web of Science and Google Scholar. Results: It can be observed that, of the metabolic processes involved, inflammation and renal hypoxia, which are mutually related, are variables of interest to be considered in this type of injury. Understanding and monitoring the impact of mineral deposition and / or the formation of crystals in the renal parenchyma is an extremely important factor in this context. Conclusion: Mineral imbalance and the urinary saturation of some crystallization promoters, such as oxalate, as well as the inflammation and hypoxemia process, make the kidney environment prone to acute or chronic disorders, possibly due to the disconnected of these variables. Keywords: Oxalate; hypoxia; vascular calcification; renal failure, chronic; COVID-19

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Section: Aspectos Fisiopatológicosunclassified

Renal hypoxia, vascular calcification and crystalline nephropathy

Gomes¹

2022

Rev Pat Tocantins

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Dislipidemia associada à doença renal crônica – Revisão de literatura

Cited by 1 publication

References 36 publications

Renal hypoxia, vascular calcification and crystalline nephropathy

Renal hypoxia, vascular calcification and crystalline nephropathy

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