Disk-based one-dimensional photonic crystal slabs for label-free immunosensing

Abstract

One-dimensional photonic crystal slabs are periodic optical nanostructures that produce guided-mode resonance. They couple part of the incident light into the waveguide generating bandgaps in the transmittance spectrum, whose position is sensitive to refractive index variations on their surface. In this study, we present one-dimensional photonic crystal slab biosensors based on the internal nanogrooved structure of Blu-ray disks for label-free immunosensing. We demonstrated that this polycarbonate structure coated with a critical thickness of TiO2 generates guided-mode resonance. Its optical behavior was established comparing it with other compact disk structures. The results were theoretically calculated and experimentally demonstrated, all them being in agreement. The bioanalytical performance of these photonic crystals was experimentally demonstrated in a model assay to quantify IgGs as well as in two immunoassays to determine the biomarkers C-reactive protein and lactate dehydrogenase (detection limits of 0.1, 87, and 13 nM, respectively). The results are promising towards the development of new low-cost, portable, and label-free optical biosensors that join these photonic crystals with dedicated bioanalytical scanners based on compact disk drives.

Responsive principles and applications of smart materials in biosensing

“…PC structures also has many applications for the detection of various proteins [ 76 ]. Asher group was pioneer in the development of PC-based sensors to detect chemical or biological targets [ 48 , 77 ].…”

Plasmonic Metasensors Based on 2D Hybrid Atomically Thin Perovskite Nanomaterials

“…At the beginning of market development, biosensing products typically require time-consuming and costly labelling processes, where a receptor is used with a fluorescent molecule bound with the target analytes. To achieve simple and fast detection, various label-free biosensing technologies [14][15][16][17] have been investigated and demonstrated. Plasmonic sensors or surface plasmon resonance (SPR) sensors are one of the most commonly-used optical sensing devices for real-time monitoring of chemical and biomolecular interactions [18][19][20][21][22][23].…”

“…At the beginning of market development, biosensing products typically require time-consuming and costly labelling processes, where a receptor is used with a fluorescent molecule bound with the target analytes. To achieve simple and fast detection, various label-free biosensing technologies [ 14 , 15 , 16 , 17 ] have been investigated and demonstrated.…”

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