Disintegrating Health Services and Resurgent Tuberculosis in Post-Soviet Tajikistan: An Example of Structural Violence

The Crystal Structure of Mycobacterium tuberculosisAlkylhydroperoxidase AhpD, a Potential Target for Antitubercular Drug Design

“…2,3 This catalytic motif consists of two cysteines separated by two amino acid residues. The two spacer residues differ, being Ser-His in the mycobacterial proteins, Gly-Met in the Brucella melitensis and Streptomyces proteins, and His-Phe in the Ralstonia solanacearum protein.…”

“…Furthermore, it is estimated that ϳ2 billion people have been exposed to Mycobacterium tuberculosis and thus are at risk of developing the active disease. Although most of the infected individuals reside in less industrialized countries, the rates of infection in areas undergoing rapid social change, such as the countries of the former Soviet Union, are also increasing at an alarming rate (2). In part because of the symbiotic relationship between human immunodeficiency virus and tuberculosis, and the increasingly rapid displacement of populations, the incidence of multidrug-resistant tuberculosis is an important worldwide concern.…”

A novel inhibitor of indole‐3‐glycerol phosphate synthase with activity against multidrug‐resistant Mycobacterium tuberculosis

“…Tuberculosis (TB) is the leading cause of infectious morbidity and mortality worldwide, with nine million new cases and two million deaths per year (http://www.tballiance.org). Approximately two billion people are latently infected with Mycobacterium tuberculosis , comprising a critical reservoir for disease reactivation [1]. The alarming increase in drug‐resistant TB, especially multidrug‐resistant TB (MDR‐TB, resistant to at least isoniazid and rifampin), poses a significant threat to effective TB control [2].…”

Inhibition of Mycobacterium tuberculosis AhpD, an Element of the Peroxiredoxin Defense against Oxidative Stress

“…It is estimated that approximately 2 billion people are infected with Mycobacterium tuberculosis (14). The symbiosis between human immunodeficiency virus and tuberculosis, together with the appearance of multidrug-resistant strains, has contributed greatly to the resurgence of the disease (18).…”