Disentangling Genetic Variation for Resistance and Endurance to Scuticociliatosis in Turbot Using Pedigree and Genomic Information

Saura, María; Carabaño, M. J.; Fernández, Almudena; Cabaleiro, Santiago; Doeschl‐Wilson, Andrea; Anacleto, Osvaldo; Maroso, Francesco; Millán, Adrián; Hermida, Miguel; Fernández, Carlos; Martı́nez, Paulino; Villanueva, Beatriz

doi:10.3389/fgene.2019.00539

Cited by 37 publications

(43 citation statements)

References 71 publications

(87 reference statements)

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“…Despite different breeding strategies, the same traits have been targeted in the turbot breeding programs, i.e., growth-related traits and resistance to major infectious diseases affecting turbot production (Sánchez-Molano et al, 2011;Rodríguez-Ramilo et al, 2014), suggesting that processes of convergent selection may have shaped the genome of the different turbot broodstock. We analyzed a random sample of the CETGA broodstock consisting of 46 breeders, which were additionally used for the foundation of 44 families (average of 39.5 individuals and range of 36-45 individuals per family) in the framework of the FISHBOOST project (EU 613611; Anacleto et al, 2019;Saura et al, 2019). Twenty-six of these 44 families were used in this study in order to determine the best parameters for ROH calling.…”

Section: Domestic Individualsmentioning

confidence: 99%

Genomic Signatures After Five Generations of Intensive Selective Breeding: Runs of Homozygosity and Genetic Diversity in Representative Domestic and Wild Populations of Turbot (Scophthalmus maximus)

et al. 2020

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Aramburu et al. Genomic Signatures of Selection in Turbot and one in both populations; one (broodstock) and two (wild) of those were found in significant regions retained under more restrictive ZHp criteria in the broodstock and the wild population, respectively. Genome mining and functional enrichment within regions associated with selective sweeps disclosed relevant genes and pathways related to aquaculture target traits, including growth and immune-related pathways, metabolism and response to hypoxia, which showcases how this genome atlas of genetic diversity can be a valuable resource to look for candidate genes related to natural or artificial selection in turbot populations.

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Section: Domestic Individualsmentioning

confidence: 99%

Genomic Signatures After Five Generations of Intensive Selective Breeding: Runs of Homozygosity and Genetic Diversity in Representative Domestic and Wild Populations of Turbot (Scophthalmus maximus)

et al. 2020

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“…Fastgrowth animals showed an improved resistance to the intestinal parasite E. leei. A positive correlation between growth and disease resilience was found in other sh species, such as turbot for a parasitic ciliate [65]. However, this is not universal, as growth selection was found to be positively correlated with disease susceptibility in other sh species [87,88].…”

Section: Discussionmentioning

confidence: 97%

“…Breeding programs in aquaculture are mainly focused on genetic gain in growth rate and feed e ciency and evaluate these productive traits at harvest [21,22]. In addition, selection to improve disease resilience has also become a highly desirable breeding goal and has been studied against different pathogens including parasites [65,66]. The heritability of different traits linked to growth selection has also been documented.…”

Section: Discussionmentioning

confidence: 99%

Genetic selection for growth drives differences in intestinal microbiota composition and parasite disease resistance in gilthead sea bream

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Naya-Català

Perera

et al. 2020

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Background The key effects of intestinal microbiota in animal health has led to an increasing interest in manipulating these bacterial populations to improve animal welfare. The aquaculture sector is no exception and in the last years many studies have described these populations in different fish species. However, this is not an easy task, as intestinal microbiota is composed of very dynamic populations that are influenced by different factors, such as diet, environment, host age and genetics. In the current study, we aimed to determine whether the genetic background of gilthead sea bream ( Sparus aurata ) influences the intestinal microbial composition, how these bacterial populations are modulated by dietary changes, and the effect of selection by growth on intestinal disease resistance. To that aim, three different groups of five families of gilthead sea bream that were selected during two generations for fast, intermediate or slow growth (F3 generation) were kept together in the same open-flow tanks and fed a control or a well-balanced plant-based diet during nine months. Six animals per family and dietary treatment were sacrificed and the adherent bacteria from the anterior intestinal portion were sequenced. In parallel, fish of the fast- and slow-growth groups were infected with the intestinal parasite Enteromyxum leei and the disease signs, prevalence, intensity and parasite abundance were evaluated. Results No differences were detected in alpha diversity indexes among families, and the core bacterial architecture was the prototypical composition of gilthead sea bream intestinal microbiota, indicating no dysbiosis in any of the groups. The plant-based diet significantly changed the microbiota in the intermediate- and slow-growth families, with a much lower effect on the fast-growth group. Interestingly, the smaller changes detected in the fast-growth families potentially accounted for more changes at the metabolic level when compared to the other families. Upon parasitic infection, the fast-growth group showed significantly lower disease signs and parasite intensity and abundance than the slow-growth animals. Conclusions These results show a clear genome-metagenome interaction indicating that the fast-growth families harbor a microbiota that is more flexible upon dietary changes. These animals also showed a better ability to cope with intestinal infections.

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Section: Discussionmentioning

confidence: 99%

Genetic selection for growth drives differences in intestinal microbiota composition and parasite disease resistance in gilthead sea bream

Piazzon

Naya-Català

Perera

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The key effects of intestinal microbiota in animal health has led to an increasing interest in manipulating these bacterial populations to improve animal welfare. The aquaculture sector is no exception and in the last years many studies have described these populations in different fish species. However, this is not an easy task, as intestinal microbiota is composed of very dynamic populations that are influenced by different factors, such as diet, environment, host age and genetics. In the current study, we aimed to determine whether the genetic background of gilthead sea bream (Sparus aurata) influences the intestinal microbial composition, how these bacterial populations are modulated by dietary changes, and the effect of selection by growth on intestinal disease resistance. To that aim, three different groups of five families of gilthead sea bream that were selected during two generations for fast, intermediate or slow growth (F3 generation) were kept together in the same open-flow tanks and fed a control or a well-balanced plant-based diet during nine months. Six animals per family and dietary treatment were sacrificed and the adherent bacteria from the anterior intestinal portion were sequenced. In parallel, fish of the fast- and slow-growth groups were infected with the intestinal parasite Enteromyxum leei and the disease signs, prevalence, intensity and parasite abundance were evaluated. Results: No differences were detected in alpha diversity indexes among families, and the core bacterial architecture was the prototypical composition of gilthead sea bream intestinal microbiota, indicating no dysbiosis in any of the groups. The plant-based diet significantly changed the microbiota in the intermediate- and slow-growth families, with a much lower effect on the fast-growth group. Interestingly, the smaller changes detected in the fast-growth families potentially accounted for more changes at the metabolic level when compared to the other families. Upon parasitic infection, the fast-growth group showed significantly lower disease signs and parasite intensity and abundance than the slow-growth animals. Conclusions: These results show a clear genome-metagenome interaction indicating that the fast-growth families harbor a microbiota that is more flexible upon dietary changes. These animals also showed a better ability to cope with intestinal infections.

show abstract

Disentangling Genetic Variation for Resistance and Endurance to Scuticociliatosis in Turbot Using Pedigree and Genomic Information

Cited by 37 publications

References 71 publications

Genomic Signatures After Five Generations of Intensive Selective Breeding: Runs of Homozygosity and Genetic Diversity in Representative Domestic and Wild Populations of Turbot (Scophthalmus maximus)

Genomic Signatures After Five Generations of Intensive Selective Breeding: Runs of Homozygosity and Genetic Diversity in Representative Domestic and Wild Populations of Turbot (Scophthalmus maximus)

Genetic selection for growth drives differences in intestinal microbiota composition and parasite disease resistance in gilthead sea bream

Genetic selection for growth drives differences in intestinal microbiota composition and parasite disease resistance in gilthead sea bream

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