Diseases of the Digital Soft Tissues

Berry, Steven L.

doi:10.1016/s0749-0720(15)30058-x

Cited by 27 publications

(37 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In many instances, the occurrence of PDD is linked to the introduction of replacement cows into the herd (20,28). PDD lesions generally do not heal spontaneously and may progress to a severe state involving the horny tissue junction of the foot resulting in loss of the hoof in erosive lesions (3). Parenteral and topical antibiotics and footbaths are effective treatments for this disease.…”

mentioning

confidence: 99%

Lesion Formation and Antibody Response Induced by Papillomatous Digital Dermatitis-Associated Spirochetes in a Murine Abscess Model

2007

View full text Add to dashboard Cite

Papillomatous digital dermatitis (PDD), also known as hairy heel wart, is a growing cause of lameness of cows in the U.S. dairy industry. Farms with PDD-afflicted cows experience economic loss due to treatment costs, decreased milk production, lower reproductive efficiency, and premature culling. While the exact cause of PDD is unknown, lesion development is associated with the presence of anaerobic spirochetes. This study was undertaken to investigate the virulence and antigenic relatedness of four previously isolated Treponema phagedenis-like spirochetes (1A, 3A, 4A, and 5B) by using a mouse abscess model with subcutaneous inoculation of 10 9 , 10 10 , and 10 11 spirochetes. Each of the PDD isolates induced abscess formation, with strain 3A causing cutaneous ulceration. Lesion development and antibody responses were dose dependent and differed significantly from those seen with the nonpathogenic human T. phagedenis strain. Strains 3A, 4A, and 5B showed two-way cross-reactivity with each other and a one-way cross-reaction with T. phagedenis. Strain 5B showed one-way cross-reactivity with 1A. None of the isolates showed cross-reactivity with T. denticola. In addition, distinct differences in immunoglobulin G subclass elicitation occurred between the PDD strains and T. phagedenis. From these data, we conclude that spirochetes isolated from PDD lesions have differential virulence and antigenic traits in vivo. Continuing investigation of these properties is important for the elucidation of virulence mechanisms and antigenic targets for vaccine development.

show abstract

mentioning

confidence: 99%

Lesion Formation and Antibody Response Induced by Papillomatous Digital Dermatitis-Associated Spirochetes in a Murine Abscess Model

2007

View full text Add to dashboard Cite

show abstract

“…Infectious claw diseases continue to affect cattle in intensively managed husbandry systems. Poor foot hygiene and constantly moist environments lead to the infection and spread of diseases such as digital dermatitis (DD; hairy heel warts), interdigital phlegmon (foot rot), and interdigital dermatitis (ID) with heel horn erosion (slurry heel) (Berry, 2001;Somers et al, 2005). Digital dermatitis was first documented in Italy in 1974 (Cheli and Mortellaro, 1974) and has since dramatically increased in prevalence, becoming one of the major causes of lameness in dairy cattle throughout the world (Wells et al, 1999;Yeruham et al, 2000;Manske et al, 2002;Somers et al, 2005;van Andel et al, 2012).…”

Section: Short Communicationmentioning

confidence: 99%

“…Other bacterial species that may play a role in the etiology of DD and have been isolated from lesions are Fusobacterium spp., Campylobacter spp., Peptococcus spp., Prevotella spp., Porphyromonas spp., and Dichelobacter nodosus (Dopfer et al, 1997;Ohya et al, 1999;Berry et al, 2010;Moe et al, 2010). Many of the microorganisms that are involved in DD are also involved in ID and foot rot (Berry, 2001). Specifically, Dichelobacter spp., Fusobacterium spp., and Porphyromonas spp.…”

Section: Short Communicationmentioning

confidence: 99%

Short communication: Determination of the ability of Thymox to kill or inhibit various species of microorganisms associated with infectious causes of bovine lameness in vitro

Kulow

Zibaee

Allard³

et al. 2015

Journal of Dairy Science

View full text Add to dashboard Cite

Infectious claw diseases continue to plague cattle in intensively managed husbandry systems. Poor foot hygiene and constant moist environments lead to the infection and spread of diseases such as digital dermatitis (hairy heel warts), interdigital dermatitis, and interdigital phlegmon (foot rot). Currently, copper sulfate and formalin are the most widely used disinfecting agents in bovine footbaths; however, the industry could benefit from more environmentally and worker friendly substitutes. This study determined the in vitro minimum inhibitory concentrations and minimum bactericidal concentrations of Thymox (Laboratoire M2, Sherbrooke, Québec, Canada) for a selection of microorganisms related to infectious bovine foot diseases. Thymox is a broad-spectrum agricultural disinfectant that is nontoxic, noncorrosive, and readily biodegradable. The values for minimum inhibitory concentration and minimum bactericidal concentration indicated that Thymox inhibited growth and killed the various species of microorganisms under study at much lower concentrations compared with the recommended working concentration of a 1% solution. Overall, the values found in this study of minimum inhibitory concentration and minimum bactericidal concentration of Thymox show its potential as an alternative antibacterial agent used in bovine footbaths; however, field trials are needed to determine its effectiveness for the control and prevention of infectious claw diseases.

show abstract

“…However, some degree of recurrence of the DD lesions has also been frequently reported. The condition has been reported as a major cause of lameness in numerous countries (Blowey & Sharp 1988, Read & Walker 1998, Argaez-Rodriguez et al 1997, RodriguezLainz et al 1999, Berry 2001). In Brazil, preliminary studies already indicated the occurrence of DD since the mid1990s (Borges et al 1992, Molina et al 1999; however, DD lesions were later studied by Cruz et al (2001Cruz et al ( , 2005.…”

Section: Introductionmentioning

confidence: 99%

“…DD lesions usually occur on the hind feet at or above the plantar interdigital ridge adjacent to the bulbs of the heels (Blowey & Sharp 1988, Döpfer et al 1997, Read & Walker 1998, Berry 2001), but DD lesions have not been reported to occur above the level of the dewclaws (Berry 2001). DD has been referred to as papillomatous digital dermatitis (PDD), verrucous dermatitis, hairy footwarts and by other names (Read & Walker 1998).…”

Section: Introductionmentioning

confidence: 99%

Digital dermatitis of the accessory digits of dairy cows

et al. 2010

View full text Add to dashboard Cite

This report characterizes the digital dermatitis (DD) lesions in the accessory digits of dairy cows and presents data on the applied therapy. Fifteen Holstein cattle with DD affecting the accessory digits of the hindlimbs from four dairy farms with previous history of DD were evaluated. Lesions were excised, the wounds were sutured, and a topical application of oxytetracycline powder covered by bandaging was associated with a single parenteral administration of long acting oxytetracycline IM (20mg/kg). Tissue samples were obtained for histopathology and transmission electronic microscopy (TEM). Lesions from all the animals were recuperated 15 days after surgical procedure. Overal, most DD lesions were papillomatous epidermal projections or wartlike verrucous lesions. Histopathologically, samples revealed hyperplasia of epidermis with hyperkeratosis, several mitoses in the stratum basale and elongated rete ridges in the superficial and middle dermis. TEM revealed long, thin spirochete-like bacteria. Morphologic features of lesions and its response to therapy were comparable to those described for DD.

show abstract

Diseases of the Digital Soft Tissues

Cited by 27 publications

References 28 publications

Lesion Formation and Antibody Response Induced by Papillomatous Digital Dermatitis-Associated Spirochetes in a Murine Abscess Model

Lesion Formation and Antibody Response Induced by Papillomatous Digital Dermatitis-Associated Spirochetes in a Murine Abscess Model

Short communication: Determination of the ability of Thymox to kill or inhibit various species of microorganisms associated with infectious causes of bovine lameness in vitro

Digital dermatitis of the accessory digits of dairy cows

Contact Info

Product

Resources

About