Disease Recurrence and Second Tumors in Long-term Survivors of Lung Cancer

Escuín, Julio Sánchez de Cos; López, D. Peiteado; Delgado, Isabel Utrabo; Domínguez, Rocío Gallego; González, M. Agustín Sojo; Valle, Manuel Hernández

doi:10.1016/j.arbr.2016.02.005

Cited by 15 publications

(15 citation statements)

References 21 publications

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“…7 Patients diagnosed with early stage lung cancer have an increased risk for second primaries compared with the general population without a prior cancer diagnosis. 30 Many second malignancies are related to smoking. The rate of second primaries is slightly lower in first primary adenocarcinoma with a rate of 3.36 per 100 person-years than in squamous cell carcinoma with a rate of 3.77 per 100 person-years.…”

Section: Multiple Primaries In Patients With Lung Cancermentioning

confidence: 99%

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Multiple primary tumours: challenges and approaches, a review

et al. 2017

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When in a patient more than one tumour in the same or a different organ is diagnosed, multiple primary tumours may be present. For epidemiological studies, different definitions of multiple primaries are used with the two main definitions coming from the project Surveillance Epidemiology and End Results and the International Association of Cancer Registries and International Agency for Research on Cancer. The differences in the two definitions have to be taken into consideration when reports on multiple primaries are analysed. In this review, the literature on multiple primaries is reviewed and summarised. Overall, the frequency of multiple primaries is reported in the range of 2–17%.Aetiological factors that may predispose patients to multiple primaries can be grouped into host related, lifestyle factors and environmental influences. Some of the most common cancer predisposition syndromes based on a clinical presentation are discussed and the relevant genetic evaluation and testing are characterised.Importantly, from a clinical standpoint, clinical situations when multiple primaries should be suspected and ruled out in a patient are discussed.Furthermore, general principles and possible treatment strategies for patients with synchronous and metachronous multiple primary tumours are highlighted.

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Section: Multiple Primaries In Patients With Lung Cancermentioning

confidence: 99%

“…There is no significant association with radiotherapy. 30 The most common second cancers are in the lung, especially if the first primary was a SCLC. The most common second lung malignancies are adenocarcinomas (29.9%) followed by squamous cell carcinomas (27.1%).…”

Section: Multiple Primaries In Patients With Lung Cancermentioning

confidence: 99%

Multiple primary tumours: challenges and approaches, a review

et al. 2017

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Section: Risk Factors Of Lcmentioning

confidence: 84%

“…In this regard, in long-term survivor patients, recurrence and the appearance of second tumors were observed in the lungs and other organs of patients with LC as early as three years after the diagnosis (12,89). As the new tumors were also related to CS, the authors concluded that the multiple carcinogenic effects of CS persist several years after the LC diagnosis in patients with long survival (12,89). Thus, novel diagnostic tools are required in order to identify patients who may be at a higher risk of LC, with a special focus on patients with a long smoking history and/ or the presence of underlying respiratory conditions such as COPD (90)(91)(92)(93).…”

Section: Risk Factors Of Lcmentioning

confidence: 99%

Relationships between chronic obstructive pulmonary disease and lung cancer: biological insights

Barreiro¹,

Bustamante

Curull³

et al. 2016

J. Thorac. Dis.

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Lung cancer (LC) has become one of the leading causes of preventable death in the last few decades. Cigarette smoking (CS) stays as the main etiologic factor of LC despite that many other causes such as occupational exposures, air pollution, asbestos, or radiation have also been implicated. Patients with chronic obstructive pulmonary disease (COPD), which also represents a major cause of morbidity and mortality in developed countries, exhibit a significantly greater risk of LC. The study of the underlying biological mechanisms that may predispose patients with chronic respiratory diseases to a higher incidence of LC has also gained much attention in the last few years. The present review has been divided into three major sections in which different aspects have been addressed: (I) relevant etiologic agents of LC; (II) studies confirming the hypothesis that COPD patients are exposed to a greater risk of developing LC; and (III) evidence on the most relevant underlying biological mechanisms that support the links between COPD and LC. Several carcinogenic agents have been described in the last decades but CS remains to be the leading etiologic agent in most geographical regions in which the incidence of LC is very high. Growing evidence has put the line forward the implications of COPD and especially of emphysema in LC development. Hence, COPD represents a major risk factor of LC in patients. Different avenues of research have demonstrated the presence of relevant biological mechanisms that may predispose COPD patients to develop LC. Importantly, the so far identified biological mechanisms offer targets for the design of specific therapeutic strategies that will further the current treatment options for patients with LC. Prospective screening studies, in which patients with COPD should be followed up for several years will help identify biomarkers that may predict the risk of LC among these patients.

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“…Our patient did not received any radiotherapy in the past, but chemotherapeutic agents administered for her treatment could cause DNA damage and that may lead to the development of a subsequent neoplasm. Treatment-related secondary malignancies are well documented in the literature 13,14 , but SCC of the colon is an extremely rare type of colonic malignancy, that has not yet been described as such. 3,15 A relationship between adenocarcinoma of the colon and ovarian carcinoma has been reported in many studies and this association has been attributed to hormonal factors, low parity and diet.…”

Section: Discussionmentioning

confidence: 99%