Disease Progression in Usual Interstitial Pneumonia Compared With Desquamative Interstitial Pneumonia

Hartman, Thomas E.; Primack, Steven L.; Kang, Eun Young; Swensen, Stephen J.; Hansell, David M.; McGuinness, Georgeann; Müller, Néstor L.

doi:10.1378/chest.110.2.378

Cited by 147 publications

(108 citation statements)

References 14 publications

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“…In patients with predominantly inflammatory (non-fibrotic) disease, manifested by peripheral GGO on HRCT, the cessation of smoking will be associated with significant improvement or resolution of the abnormalities [19,20]. Corticosteroid therapy may be used in conjunction with smoking cessation.…”

Section: Smoking-related Lung Diseasementioning

confidence: 99%

The role of high-resolution computed tomography in the follow-up of diffuse lung disease

2017

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High-resolution computed tomography (HRCT) of the lung is a key component of the multidisciplinary approach to diagnosis in diffuse lung disease (DLD). HRCT also plays an important role in the follow-up of patients with established DLD. In this respect, serial HRCT examinations may provide valuable information that cannot be determined from clinical history and other diagnostic tests, such as pulmonary function tests. Important roles of HRCT in this context include assisting in determining prognosis, monitoring for the efficacy of treatment, detecting progression of disease or complications, and evaluating patients with worsening or acute symptoms. Both clinicians and radiologists should be aware of the expected evolution of HRCT changes in a variety of DLDs. The goals of this paper are to discuss: 1) the expected evolution of HRCT findings over time in common DLDs; 2) the role of serial HRCT examinations in formulating an initial diagnosis; and 3) the role of HRCT in the follow-up of patients with known DLD.

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Section: Smoking-related Lung Diseasementioning

confidence: 99%

The role of high-resolution computed tomography in the follow-up of diffuse lung disease

2017

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“…Patients with RB-ILD or DIP are usually 30-40 yrs of age and have an average smoking history of 30 pack-yrs [7,11]; males are affected approximately twice as often as females [59,60]. Symptoms and clinical aspects in both these diseases are nonspecific.…”

Section: Clinical and Functional Aspects In Rb-ild And Dipmentioning

confidence: 99%

An integrated approach in the diagnosis of smoking-related interstitial lung diseases

Caminati

Cavazza

Sverzellati

et al. 2012

European Respiratory Review

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Cigarette smoke consists of several chemical compounds with a variety of effects in many organs. In the lung, apart being the main cause of chronic obstructive pulmonary disease, carcinoma and idiopathic spontaneous pneumothorax, tobacco smoke is associated with interstitial lung diseases (ILDs), including respiratory bronchiolitis-associated ILD (RB-ILD), desquamative interstitial pneumonia (DIP), pulmonary Langerhans' cell histiocytosis (PLCH), idiopathic pulmonary fibrosis, acute eosinophilic pneumonia, ILD in rheumatoid arthritis and pulmonary haemorrhage in Goodpasture syndrome.This review will focus on the diseases with a stronger epidemiological association with tobacco smoke, namely RB-ILD, DIP and PLCH. Although the exact pathogenetic evidence linking smoking with these disorders is still not completely understood, there is growing evidence that tobacco smoke targets the terminal or respiratory bronchioles in these diseases, and the differences are reflective of the degree of severity of small airway and parenchymal reaction to the smoke exposure.Despite considerable clinical, radiological and histological overlap between RB-ILD, DIP and PLCH, it is useful to retain the separate classifications for prognostic and therapeutic implications.

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“…Fibrosis may be present in 50-60% of the patients [34,35], but honeycombing is rare [17]. On follow-up HRCT, patients receiving treatment can show partial or complete resolution of the areas of ground-glass opacification [37]. The CT differential diagnosis includes RB-ILD, NSIP, and acute hypersensitivity pneumonitis [34].…”

Section: Desquamative Interstitial Pneumoniamentioning

confidence: 99%

“…Also, recurrence in a transplanted lung has been reported [39]. Some authors have observed a possible progression of DIP to usual interstitial pneumonia, but there is little evidence yet [37].…”

Section: Desquamative Interstitial Pneumoniamentioning

confidence: 99%

Smoking and Other Interstitial Lung Diseases

2011

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Cigarette smoking has been implicated in the development of some uncommon respiratory interstitial diseases. Desquamative interstitial pneumonia and respiratory bronchiolitis-associated interstitial lung diseases are characterized by a diffuse alveolar and peribronchiolar filling with macrophages, respectively. Pulmonary Langerhans' cell histiocytosis is a rare interstitial lung disorder characterized by the proliferation of Langerhans' cell forming interstitial infiltrates and nodules that could progress to cavitary nodules. The treatment of these disorders involves smoking cessation and sometimes the use of steroids. High-resolution computed tomography is essential for the characterization of these smoking-related interstitial lung diseases, but frequently it is necessary to create a workgroup composed by pulmonologists, pathologists, and radiologists to diagnosis and treat patients affected with these pathologies.

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Disease Progression in Usual Interstitial Pneumonia Compared With Desquamative Interstitial Pneumonia

Cited by 147 publications

References 14 publications

The role of high-resolution computed tomography in the follow-up of diffuse lung disease

The role of high-resolution computed tomography in the follow-up of diffuse lung disease

An integrated approach in the diagnosis of smoking-related interstitial lung diseases

Smoking and Other Interstitial Lung Diseases

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