2020
DOI: 10.1093/ecco-jcc/jjaa173
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Abstract: Background and aims Real-life data on long-term disease activity in Crohn’s disease (CD) are scarce. Most studies describe disease course by using proxies, such as drug exposure, need for surgery or hospitalisations, and disease progression. We aimed to describe disease course by long-term disease activity and identify distinctive disease activity patterns in the population-based IBD South Limburg cohort (IBDSL). Methods All … Show more

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Cited by 25 publications
(22 citation statements)
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“…Age and body mass index were not found to be risk factors for treatment failure in our study, but are described in literature 32‐34 . Smoking is an established risk factor for complicated disease courses in CD 35 . Smoking rates were high in our cohort (41%), but we could not identify smoking as a risk factor for treatment failure.…”
Section: Discussioncontrasting
confidence: 68%
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“…Age and body mass index were not found to be risk factors for treatment failure in our study, but are described in literature 32‐34 . Smoking is an established risk factor for complicated disease courses in CD 35 . Smoking rates were high in our cohort (41%), but we could not identify smoking as a risk factor for treatment failure.…”
Section: Discussioncontrasting
confidence: 68%
“… 32 , 33 , 34 Smoking is an established risk factor for complicated disease courses in CD. 35 Smoking rates were high in our cohort (41%), but we could not identify smoking as a risk factor for treatment failure.…”
Section: Discussionmentioning
confidence: 55%
See 1 more Smart Citation
“…Therefore, improved and stable disease includes cases in clinical remission but not in endoscopic and/or radiologic remission. According to a recently published report by Wintjens et al, 51 a "mild chronic intermittent pattern" would be similar to this category among their six disease activity patterns. They defined six disease patterns according to the frequency of active diseases during the 10-year follow-up period, and "mild chronic intermittent pattern" was defined as five or fewer quarters of disease activity.…”
Section: ) Deep Remissionmentioning
confidence: 92%
“…In a recent study, we assessed disease activity patterns in patients with CD using long-term follow-up data from the population-based IBD South-Limburg [IBDSL] cohort. 16 Almost one-third of the population experienced a quiescent disease course during the first 10 years after diagnosis, underlining the importance of adequately stratifying patients to decrease the risk of overtreatment. Yet, another third of patients experienced a severe disease course and may benefit from early intervention and tight monitoring.…”
Section: Introductionmentioning
confidence: 99%