2016
DOI: 10.18632/aging.101100
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Accumulating evidence indicates that senescent cells play an important role in many age-associated diseases. The pharmacological depletion of senescent cells (SCs) with a “senolytic agent”, a small molecule that selectively kills SCs, is a potential novel therapeutic approach for these diseases. Recently, we discovered ABT-263, a potent and highly selective senolytic agent, by screening a library of rationally-selected compounds. With this screening approach, we also identified a second senolytic agent called … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
154
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
6

Relationship

1
5

Authors

Journals

citations
Cited by 194 publications
(155 citation statements)
references
References 74 publications
1
154
0
Order By: Relevance
“…Our previous studies showed that both Michael acceptors were important for the senolytic activity of PL (Wang et al., 2016), indicating that PL may act as an irreversible inhibitor through the conjugated addition of the nucleophiles (e.g., cysteine residue) on its target protein(s) to the Michael acceptors. Taking advantage of the covalent interaction between PL and its target protein(s), we designed PL probes that can be “tagged” for protein purification and identification in live cells (Figure 1a).…”
Section: Resultsmentioning
confidence: 99%
See 4 more Smart Citations
“…Our previous studies showed that both Michael acceptors were important for the senolytic activity of PL (Wang et al., 2016), indicating that PL may act as an irreversible inhibitor through the conjugated addition of the nucleophiles (e.g., cysteine residue) on its target protein(s) to the Michael acceptors. Taking advantage of the covalent interaction between PL and its target protein(s), we designed PL probes that can be “tagged” for protein purification and identification in live cells (Figure 1a).…”
Section: Resultsmentioning
confidence: 99%
“…The CTL probe was used to subtract nonspecific proteins pulled down by our PL probe. As expected, the CTL probe was ~9‐fold less potent than the PL probe and has no selective toxicity against SCs because the senolytic activity of PL depends on the presence of both Michael acceptors (Figure 1b) (Wang et al., 2016). …”
Section: Resultsmentioning
confidence: 99%
See 3 more Smart Citations