volume 56, issue 9, P3518-3530 2013
DOI: 10.1021/jm301879g
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Abstract: ABSTRACT: Acid ceramidase (AC) is an intracellular cysteine amidase that catalyzes the hydrolysis of the lipid messenger ceramide. By regulating ceramide levels in cells, AC may contribute to the regulation of cancer cell proliferation and senescence and to the response to cancer therapy. We recently identified the antitumoral agent carmofur (4a) as the first nanomolar inhibitor of intracellular AC activity (rat AC, IC 50 = 0.029 μM). In the present work, we expanded our initial structure−activity relationshi…

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