2021
DOI: 10.1016/s2666-5247(21)00145-2
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Discovery and validation of a three-gene signature to distinguish COVID-19 and other viral infections in emergency infectious disease presentations: a case-control and observational cohort study

Abstract: Background Emergency admissions for infection often lack initial diagnostic certainty. COVID-19 has highlighted a need for novel diagnostic approaches to indicate likelihood of viral infection in a pandemic setting. We aimed to derive and validate a blood transcriptional signature to detect viral infections, including COVID-19, among adults with suspected infection who presented to the emergency department. Methods Individuals (aged ≥18 years) presenting with suspected … Show more

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Cited by 24 publications
(23 citation statements)
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“…There has been speculation that some people may have been exposed to SARS-CoV-2 on multiple occasions but without this leaving any footprint of adaptive priming because of the efficiency of innate immune mechanisms. For example, longitudinal studies of a cohort of health-care workers showed that some heavily exposed but consistently PCR- and antibody-negative individuals have a raised frequency of memory T cells that are specific for epitopes from the SARS-CoV-2 replication transcription complex, as well as low-level activation of IFI2, an early marker of innate viral recognition 45 , 46 . Such ‘neutralizing’ effector pathways will remain hard to validate until more insight is gained from human challenge studies.…”
Section: Immunity After Asymptomatic Primingmentioning
confidence: 99%
“…There has been speculation that some people may have been exposed to SARS-CoV-2 on multiple occasions but without this leaving any footprint of adaptive priming because of the efficiency of innate immune mechanisms. For example, longitudinal studies of a cohort of health-care workers showed that some heavily exposed but consistently PCR- and antibody-negative individuals have a raised frequency of memory T cells that are specific for epitopes from the SARS-CoV-2 replication transcription complex, as well as low-level activation of IFI2, an early marker of innate viral recognition 45 , 46 . Such ‘neutralizing’ effector pathways will remain hard to validate until more insight is gained from human challenge studies.…”
Section: Immunity After Asymptomatic Primingmentioning
confidence: 99%
“…When HERC6 is overexpressed, it promotes the inflammatory response (Cao et al, 2022;Scott et al, 2022). It has been mentioned that this gene is overexpressed in SARS-CoV-2 infection patients (Li et al, 2021). Human EXOG (hEXOG) is a 5′exonuclease crucial for mitochondrial DNA repair; The enzyme belongs to a family of nonspecific nucleases that includes the apoptotic endonuclease EndoG, and the accumulation of certain types of mitochondrial damage in its absence can directly trigger cell death (Van Houten et al, 2016;Szymanski et al, 2017).…”
Section: Down-or Up-regulated Genes In Sars-cov-2 and Their Possible ...mentioning
confidence: 99%
“…SARS-CoV-2 is the causative respiratory viral pathogen responsible for the COVID-19 (32). Given the need for rapid diagnostics, multiple studies explored the use of host-based (23).…”
Section: Coronavirus Disease 2019mentioning
confidence: 99%