volume 66, issue 9, P5635-5641 1992
DOI: 10.1128/jvi.66.9.5635-5641.1992
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Abstract: Monoclonal antibodies have been isolated from human immunodeficiency virus type 1 (HIV-1)-infected patients that recognize discontinuous epitopes on the gpl20 envelope glycoprotein, that block gpl20 interaction with the CD4 receptor, and that neutralize a variety of HIV-1 isolates. Using a panel of HIV-1 gp120 mutants, we identified amino acids important for precipitation of the gpl20 glycoprotein by three different monoclonal antibodies with these properties. These amino acids are located within seven discont…

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