Discoid lupus erythematosus-like skin changes in patients with autosomal recessive chronic granulomatous disease

The dermatosis of chronic granulomatous disease

“…Approximately 60 cases of CGD have appeared in the literature reporting a ‘discoid lupus erythematosus‐like rash’. 6,8–10,12–23 Of these cases, only one describes the clinical presence of follicular plugging, a hallmark of this variant of lupus erythematosus. Other clinical features which are common in DLE but absent from most of these CGD–DLE reports are clear definition of lesions including adherent scales and atrophic scarring in old lesions.…”

“…Cutaneous features include an increased tendency to skin infection such as recurrent mucous membrane infections, impetigo, carbuncles, otitis externa and suppurative lymphadenopathy. 5–7 Other less common skin conditions described in association with CGD include discoid lupus erythematosus ( Table 1), 6,8–10,12–23 aphthous stomatitis, 9 , 12–14,22 Raynaud's phenomenon, 11,13 , 14,16–19 arcuate dermal erythema and Jessner's lymphocytic infiltrate 7,11 …”

Reactive Oxygen Species Deficiency Induces Autoimmunity with Type 1 Interferon Signature

“…CGD patients are also known to have increased risk of developing systemic lupus erythematosus (SLE) (3, 12, 16, 19, 35, 56, 59, 63, 64). Anti-phospholipid syndrome, IgA neurophathy (16), Kawasaki disease (66), and polyarthritis (33) are other autoimmune manifestations reported to occur in CGD patients.…”