Discoid lupus erythematosus. Electron microscopic studies of paramyxovirus-like structures

Hashimoto, K.

doi:10.1001/archderm.101.5.565

Cited by 23 publications

(28 citation statements)

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“…Despite a superficial resemblance to the nucleoprotein cores of myxoviruses (1,2,8,22), the tubules observed in endothelial cells and lymphocytes of patients with SLE appear to lack the helical periodicity of myxovirus cores (25,28,30). In this respect, the tubules also differ from the intranuclear filaments described in chronic polymyositis or subacute sclerosing panencephalitis (31,32).…”

Section: Nature and Pathogenesis Of Trsmentioning

confidence: 94%

“…T h e involvement of lymphocytes in 2 cases of chronic discoid lupus accords with other systemic features of this apparently localized and relatively benign disease. The frequency of vascular involvement in SLE or discoid lupus may approach 100% (6,8,22) and is probably significantly greater than in other diseases (3,4,22,23). Nevertheless, T R S have also been identified in the glomeruli of some children with nephrotic syndrome (23) and in vessels supplying neoplastic tissue (24) among other conditions reviewed previously (25,26).…”

Section: Clinical Specificity and Significance Of Trsmentioning

confidence: 94%

“…In this respect, the tubules also differ from the intranuclear filaments described in chronic polymyositis or subacute sclerosing panencephalitis (31,32). Known myxoviruses always form within the nucleus or cytoplasm (25,30,31), whereas T R S can usually be identified within membrane-limited compartments connected to the endoplasmic reticulum or perinuclear cisternum (8,22,25,28).…”

Section: Nature and Pathogenesis Of Trsmentioning

confidence: 96%

“…Structures indistinguishable from the T R S in SLE were reported by Baringer (27) in the brain of a patient with herpetic encephalitis as well as the brains of rabbits infected experimentally with herpes simplex virus. Tubuloreticular structures were also identified in a case of coxsackie myocarditis (28) and in congenital rubella (8). T h e formation of T R S in capillary endothelial cells of horses infected with equine arteritis virus (29) offers a provoking parallel to SLE.…”

Section: Nature and Pathogenesis Of Trsmentioning

confidence: 99%

“…systemic lupus erythematosus (SLE) (3)(4)(5)(6) and many patients with related diseases of connective tissues (7)(8)(9). We now report a significant frequency of morphologically identical structures in the circulating lymphocytes of such patients.…”

mentioning

confidence: 99%

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Abnormal Structures in Circulating Lymphocytes from Patients with Systemic Lupus Erythematosus and Related Diseases

Grimley

Decker

Michelitch

et al. 1973

Arthritis & Rheumatism

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A prospective electron microscopic study, incorporating blind controls, demonstrated tubuloreticular structures (TRS) in the buffy coat lymphocytes of 32 patients with connective tissue disease. From 1 to 8% of the lymphocyte sections were involved. The abnormal structures consisted of interwoven, electron-dense tubules (220 to 280 A diameter) which were located within the endoplasmic reticulum. Tubuloreticular structures were found in lymphocytes from 20 of 30 patients with systemic lupus erythematosus (SLE), 2 of 4 with discoid lupus erythematosus, 8 of 20 with other connective tissue disease and none of 22 control cases. Clinical evaluation of the patients with SLE disclosed no specific differences between those with TRS-positive or TRS-negative lymphocytes; there were some indications of greater disease activity in the TRS-positive group. The biologic nature of TRS is unknown, but they have been linked to virus infection under both clinical and experimental conditions. systemic lupus erythematosus (SLE) (3-6) and many patients with related diseases of connective tissues (7-9). We now report a significant frequency of morphologically identical structures in the circulating lymphocytes of such patients.T h e tubules in question have been distinguished by their ultrastructural appearance. They are relatively electron-dense and measure in the range of 220 to 280 A in diameter. They are interwoven within membrane-limited compartments which can often be identified as dilatations of the endoplasmic reticulum or perinuclear space. T h e biologic nature of these structures is still unknown, and we have adopted the description tu buloreticular struclures (TRS) also proposed by Dalton (1 0).T h e possibility of finding T R S in circulating cells was suggested by electron microscopic examination of a skin biopsy from a 24-year-old man with SLE with subcutaneous nodules and histologic evidence of chronic vasculitis. Thin

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