Directly observed treatment short course for tuberculosis. What happens to them in the long term?

Joseph, Mariamma; Thomas, Roshan Anna; Nair, Sanjeev; Balakrishnan, Shibu; Jayasankar, S.

doi:10.1016/j.ijtb.2015.02.005

Cited by 10 publications

(16 citation statements)

References 14 publications

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“…Here, the determinant factors for unsuccessful TB treatment outcome were: not receiving DOTS and TB treatment duration of <6 months. Our findings are supported by other studies that reported that DOTS can improve the cure rate (7,21). By contrast, a qualitative study showed that the rigidity of DOTS was one of the factors of treatment non-adherence by patients with TB-HIV, which led to treatment default and therefore unsuccessful treatment outcome (22).…”

Section: Discussionsupporting

confidence: 87%

 Tuberculosis Treatment Outcome In Patients With Tb-Hiv Co-Infection In Kuala Lumpur, Malaysia

Selimin

Ismail²,

Ahmad

et al. 2019

Preprint

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Background Tuberculosis (TB) is a serious health threat to people living with human immunodeficiency virus (HIV). This study aimed to identify the characteristics, unsuccessful TB treatment rate and determinants of unsuccessful TB treatment outcome among patients with TB-HIV co-infection in Kuala Lumpur.Methods This was a cross-sectional study. The data of all patients with TB-HIV in the federal territory of Kuala Lumpur from 2013 to 2017 were collected and reviewed. The data were retrieved from the national database (TB Information System) at the Kuala Lumpur Health Department from 1 March 2018 to 31 May 2018.Results Out of 235 randomly selected patients with TB-HIV, TB treatment outcome was successful in 57.9% (cured and completed treatment) and unsuccessful in 42.1% (died, failed or defaulted treatment). Patients who did not receive DOTS (directly observed treatment, short course) (adjusted odds ratio [aOR] 21.71; 95% confidence interval [CI]: 5.36–87.94) and those who received shorter treatment duration of <6 months (aOR 34.54; 95% CI: 5.97–199.93) had higher odds for unsuccessful TB treatment outcome.Conclusions Nearly half of the patients with TB-HIV had unsuccessful TB treatment outcome. Therefore, it is important to ensure that such patients receive DOTS and continuous TB treatment of >6 months. It is crucial to strengthen and widen the coverage of DOTS, especially among high-risk groups, in healthcare settings. Strict follow-up by healthcare providers is needed for patients with TB-HIV to gain treatment adherence and for better rates of successful TB treatment.

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Section: Discussionsupporting

confidence: 87%

 Tuberculosis Treatment Outcome In Patients With Tb-Hiv Co-Infection In Kuala Lumpur, Malaysia

Selimin

Ismail²,

Ahmad

et al. 2019

Preprint

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“…Since there is criticism of the directly observed treatment alone (9)(10)(11) , we analyzed the DOTS strategy as a whole, and therefore, an implementation evaluation was obtained, on which one can discuss and identify the strengths and limitations for the success of the strategy.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the implementation of the directly observed treatment strategy for tuberculosis in a large city

Lavôr

Pinheiro

Gonçalves

2016

Rev. esc. enferm. USP

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Objective: To assess the degree of implementation of the Directly Observed Treatment, Short-course -DOTS for tuberculosis (TB) in a large city. Method: Assessment of the implementation of the logic model, whose new cases of infectious pulmonary TB were recruited from specialized clinics and followed-up in basic health units. The judgment matrix covering the five components of the DOTS strategy were used. Results: The result of the logic model indicates DOTS was partially implemented. In external, organizational and implementation contexts, the DOTS strategy was partially implemented; and, the effectiveness was not implemented. Conclusion: The partial implementation of the DOTS strategy in the city of Manaus did not reflect in TB control compliance, leading to low effectiveness of the program. descriPtOrs Tuberculosis; Directly Observed Therapy; Health Evaluation; Program Evaluation; Public Health Nursing.Evaluation of the implementation of the directly observed treatment strategy for tuberculosis in a large city Avaliação da implantação da estratégia de tratamento diretamente observado para tuberculose em um município de grande porte Evaluación de la implantación de la estrategia de tratamiento directamente observado para tuberculosis en un municipio de gran porte Evaluation of the implementation of the directly observed treatment strategy for tuberculosis in a large city

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“…Relatively few prospective studies have reported the health outcomes of cured patients. In a retrospective study by Joseph et al .,[14] 73.6% of cases were healthy. A systematic review by Cox et al .…”

Section: Discussionmentioning

confidence: 99%

“…Among TB patients who had successfully completed treatment, varying mortality rates have been reported,[121314] and it has been suggested that the treatment outcome may not reflect final status of the patient. [15]…”

Section: Introductionmentioning

confidence: 99%

Prospective 1-year follow-up study of all cured, new sputum smear positive tuberculosis patients under the Revised National Tuberculosis Control Program in Hyderabad, Telangana State, India

Mathur

Chatla²,

Syed

et al. 2019

Lung India

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Background:Tuberculosis (TB) is one of the leading causes of mortality in India. The Revised National Tuberculosis Control Program (RNTCP) is a robust public health system to deal with TB in India. Unless the treated patient comes back to the system with signs and symptoms of TB due to relapse or re-infection, there is no mechanism of follow-up or any method to know the relapse rate in the population. We attempted to follow the patients declared as “Cured” as per the RNTCP guidelines for 1–2 years to identify the health status of the index cases and their household contacts in posttreatment phase.Materials and Methods:In this prospective cohort study, 187 index cases, who were declared “Cured” in six randomly selected TB units of Hyderabad district, were followed up for 1–2 years through home visits by trained staff with structured data collection forms. Data were analyzed using SPSS v20.0.Results:The mean age of the index cases was 33.64 (±16.10) years, and there were 75 females and 112 males. The study sample was homogenous for gender, age, smear grade, religion, marital status, smoking status, alcohol consumption, and human immunodeficiency virus status, etc., At 1-year posttreatment follow-up of 187 index cases, 143 (76.47%) were healthy and working without any symptoms of TB. Symptoms of TB were present in 26 (13.90%) cases, and seven index cases (4.06%) were re-diagnosed with TB. The 2-year posttreatment survival was 92%.Conclusion:Long-term follow-up of cured, new smear-positive TB cases reinforce the effectiveness of anti-TB treatment under the RNTCP as assessed by improved health outcomes in more than two-thirds of cases and posttreatment survival of 92% of index cases. We recommend continuing such follow-up for all TB cases treated under the RNTCP for effective end-TB strategy.

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Directly observed treatment short course for tuberculosis. What happens to them in the long term?

Cited by 10 publications

References 14 publications

Tuberculosis Treatment Outcome In Patients With Tb-Hiv Co-Infection In Kuala Lumpur, Malaysia

Tuberculosis Treatment Outcome In Patients With Tb-Hiv Co-Infection In Kuala Lumpur, Malaysia

Evaluation of the implementation of the directly observed treatment strategy for tuberculosis in a large city

Prospective 1-year follow-up study of all cured, new sputum smear positive tuberculosis patients under the Revised National Tuberculosis Control Program in Hyderabad, Telangana State, India

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Directly observed treatment short course for tuberculosis. What happens to them in the long term?

Cited by 10 publications

References 14 publications

&nbsp;Tuberculosis Treatment Outcome In Patients With Tb-Hiv Co-Infection In Kuala Lumpur, Malaysia

&nbsp;Tuberculosis Treatment Outcome In Patients With Tb-Hiv Co-Infection In Kuala Lumpur, Malaysia

Evaluation of the implementation of the directly observed treatment strategy for tuberculosis in a large city

Prospective 1-year follow-up study of all cured, new sputum smear positive tuberculosis patients under the Revised National Tuberculosis Control Program in Hyderabad, Telangana State, India

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Tuberculosis Treatment Outcome In Patients With Tb-Hiv Co-Infection In Kuala Lumpur, Malaysia

Tuberculosis Treatment Outcome In Patients With Tb-Hiv Co-Infection In Kuala Lumpur, Malaysia