1999
DOI: 10.1359/jbmr.1999.14.7.1167
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Abstract: The appearance of cancellous bone architecture is different for various skeletal sites and various disease states. During aging and disease, plates are perforated and connecting rods are dissolved. There is a continuous shift from one structural type to the other. So traditional histomorphometric procedures, which are based on a fixed model type, will lead to questionable results. The introduction of three-dimensional (3D) measuring techniques in bone research makes it possible to capture the actual architectu… Show more

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citations
Cited by 1,179 publications
(990 citation statements)
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References 25 publications
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“…The method yields two-dimensional representations of the TB network architecture from which the third dimension is obtained in an inferential manner using the mathematical tools of stereology (12). Since TB networks are inherently three-dimensional, 2D histomorphometric approaches have, in recent years, been superseded by direct 3D analysis of biopsy specimens imaged by micro-computed tomography (m-CT) (13). Commercial desktop m-CT instruments, available from several manufacturers, are now indispensable research tools.…”
Section: Non-invasive Assessment Of Bone Architecture Mri Versus Ctmentioning
confidence: 99%
See 2 more Smart Citations
“…The method yields two-dimensional representations of the TB network architecture from which the third dimension is obtained in an inferential manner using the mathematical tools of stereology (12). Since TB networks are inherently three-dimensional, 2D histomorphometric approaches have, in recent years, been superseded by direct 3D analysis of biopsy specimens imaged by micro-computed tomography (m-CT) (13). Commercial desktop m-CT instruments, available from several manufacturers, are now indispensable research tools.…”
Section: Non-invasive Assessment Of Bone Architecture Mri Versus Ctmentioning
confidence: 99%
“…Hildebrand et al's structure model index (SMI) provides quantitative information on the bone's plate or rod character (13,124). It is based on the idea that the partial derivative @V/@r (where V and r represent the volume and 'radius' of a structural element, respectively) is a function of the element's curvature.…”
Section: Structure Analysismentioning
confidence: 99%
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“…MicroCT-The microcomputerized tomography machine and the analyzing software were obtained from SkyScan [20,21]. Rabbit ulna analysis started just above the site of the critical size defect and continued in the dorsoventral direction embracing the entire ulnar defect and the healthy radius.…”
Section: Methodsmentioning
confidence: 99%
“…However, only new trabecular bone in the ulnar defect was depicted and analyzed in three dimensions. Rat femur analysis started by determining the connection of proximal growth plates as a reference point from which 100 slices distally were set as offset and 200 slices were analyzed for trabecular bone and new bone formation [21].…”
Section: Methodsmentioning
confidence: 99%