1995
DOI: 10.1111/j.1558-5646.1995.tb02301.x
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Abstract: An important issue in the study of the evolution of aging in Drosophila melanogaster is whether decreased early fecundity is inextricably coupled with increased life span in selection experiments on age at reproduction. Here, this problem has been tackled using an experimental design in which selection is applied directly to longevity. Selection appeared successful for short and long life, in females as well as males. Progeny production of females selected for long life was lower than for short-lived females t… Show more

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Cited by 239 publications
(202 citation statements)
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References 63 publications
(79 reference statements)
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“…101 While inconsistencies have been observed, [102][103][104][105] these studies clearly demonstrate that wild-derived lines harbor genetic variation at loci that affect aging, and that longevity tends to correlate negatively with reproduction and positively with stress and starvation tolerance. One study has performed direct artificial selection on lifespan in D. melanogaster, 106 and results support these same correlations between longevity, reproduction and stress tolerance. Identification of aging genes by induced mutation, transgenics or QTL analysis has begun to improve our understanding of the number, type and magnitude of effect of genes that affect lifespan.…”
Section: Complexity Of Genetic Architecturementioning
confidence: 67%
“…101 While inconsistencies have been observed, [102][103][104][105] these studies clearly demonstrate that wild-derived lines harbor genetic variation at loci that affect aging, and that longevity tends to correlate negatively with reproduction and positively with stress and starvation tolerance. One study has performed direct artificial selection on lifespan in D. melanogaster, 106 and results support these same correlations between longevity, reproduction and stress tolerance. Identification of aging genes by induced mutation, transgenics or QTL analysis has begun to improve our understanding of the number, type and magnitude of effect of genes that affect lifespan.…”
Section: Complexity Of Genetic Architecturementioning
confidence: 67%
“…A number of recent microarray studies have found that metabolic genes are disproportionately influenced by environmental stress, senescence, and inbreeding treatments (Girardot et al 2004;Landis et al 2004;Wang et al 2004;Englander 2005;Kristensen et al 2005). At a broad level, the role of metabolism in these processes may account for interactions between environmental stress and the magnitude of inbreeding depression (Crnokrak and Roff 1999;Keller and Waller 2002;Armbruster and Reed 2005), quantitative genetic correlations between stress resistance and extended life span Rose et al 1992;Force et al 1995;Zwaan et al 1995;Chippindale et al 1998;Norry and Loeschcke 2003), and similarities among the molecular effects of stress, inbreeding, and aging treatments observed in several species (Chen et al 2002;Brunet et al 2004;Lamming et al 2004;Colotti et al 2005;Kristensen et al 2005).…”
Section: Discussionmentioning
confidence: 99%
“…Several studies have noted a positive phenotypic correlation between Drosophila body size and lifespan Farquhar, 1981, 1983;Partridge et al, 1986), while genetic correlations between these traits have been either positive (Tantawy and Rakha, 1964;Tantawy and el-Helw, 1966;Partridge and Fowler, 1992), or have not been detected (Zwaan et al, 1995).…”
Section: Body Size and Lifespan In Drosophilamentioning
confidence: 99%