Direct pulp capping procedures – Evidence and practice

Islam, Rafiqul; Islam, Md Refat Readul; Tanaka, Toru; Alam, Mohammad Khursheed; Ahmed, Hany Mohamed Aly; Sano, Hidehiko

doi:10.1016/j.jdsr.2023.02.002

Cited by 23 publications

(34 citation statements)

References 151 publications

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“…The specimens were placed in Eppendorf tubes containing 2 mL calcium-free DPBS (Dulbecco's Phosphate Buffered Saline; Lonza, Lonza Walkersville Inc., Walkersville, MD, USA) immediately after reaching the setting time stated by the manufacturer. DPBS is a physiological-like buffered (pH 7.4) Ca-and Mg-free solution with the following composition (mM): K + (4.18), Na + (152.9), Cl − (139.5), PO 4 3− (9.56, sum of H 2 PO 4 ) 1.5 mM and HPO 4 2− 8.06 mM). Specimens were stored at 37 • C. The evaluation was performed at various incubation times: after setting, 24 h, 7, 14, and 28 days.…”

Section: Sample Preparation and Incubation In Dpbsmentioning

confidence: 99%

“…Moreover, according to the European Society of Endodontology (ESE), a more selective caries excavation should be prioritised to complete caries excavation in order to avoid unnecessary pulp exposure, which may lead to the necessity for root canal treatment (RCT) [1][2][3]. There is a growing interest in dental research on innovative materials for the management of pulp using vital pulp therapies (VPTs)-namely pulp capping (PC) [4]. This is because in our modern society, where life span has increased significantly, minimally invasive clinical procedures fulfil the task of postponing non-vital treatments and tooth loss [5].…”

Section: Introductionmentioning

confidence: 99%

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Dentine Remineralisation Induced by “Bioactive” Materials through Mineral Deposition: An In Vitro Study

Kunert,

Piwonski,

Hardan

et al. 2024

Nanomaterials

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This study aimed to assess the ability of modern resin-based “bioactive” materials (RBMs) to induce dentine remineralisation via mineral deposition and compare the results to those obtained with calcium silicate cements (CSMs). The following materials were employed for restoration of dentine cavities: CSMs: ProRoot MTA (Dentsply Sirona), MTA Angelus (Angelus), Biodentine (Septodont), and TheraCal LC (Bisco); RBMs: ACTIVA BioACTIVE Base/Liner (Pulpdent), ACTIVA Presto (Pulpdent), and Predicta Bioactive Bulk (Parkell). The evaluation of the mineral deposition was performed through scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX) on the material and dentine surfaces, as well as at the dentine–material interface after immersion in simulated body fluid. Additionally, the Ca/P ratios were also calculated in all the tested groups. The specimens were analysed after setting (baseline) and at 24 h, 7, 14, and 28 days. ProRoot MTA, MTA Angelus, Biodentine, and TheraCal LC showed significant surface precipitation, which filled the gap between the material and the dentine. Conversely, the three RBMs showed only a slight ability to induce mineral precipitation, although none of them was able to remineralise the dentine–material interface. In conclusion, in terms of mineral precipitation, modern “bioactive” RBMs are not as effective as CSMs in inducing dentine remineralisation; these latter represent the only option to induce a possible reparative process at the dentin–material interface.

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Section: Sample Preparation and Incubation In Dpbsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dentine Remineralisation Induced by “Bioactive” Materials through Mineral Deposition: An In Vitro Study

Kunert,

Piwonski,

Hardan

et al. 2024

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…As a result, vital pulp therapy (VPT) seeks to preserve the pulp tissues' vitality and functionality from potential accidents that may lead to the exposure of the vital pulp (dental caries, restorative procedures, iatrogenic etiology, and dental trauma) 3 , 4 . The VPT is divided into pulp capping (direct and indirect) and pulpotomy (miniature, partial, and complete) based on case selection and diagnosis, exposure site, root maturation, coronal restoration state, and treatment strategy 5 . Direct pulp capping (DPC) is an effective and conservative procedure among these restorative techniques 6 , which involves placing a biomaterial directly over the exposed pulp after caries removal or trauma to maintain the pulp vitality by covering the pulp exposure, preventing bacterial leakage, and promoting dentin bridge formation 7 , 8 .…”

Section: Introductionmentioning

confidence: 99%

An animal study on the effectiveness of platelet-rich plasma as a direct pulp capping agent

Elkady,

Helaly,

El Fayoumy

et al. 2024

Sci Rep

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Direct pulp capping (DPC) is a conservative approach for preserving tooth vitality without requiring more invasive procedures by enhancing pulp healing and mineralized tissue barrier formation. We investigated the effectiveness of Platelet Rich Plasma (PRP) vs. Mineral Trioxide Aggregate (MTA) as a DPC agent. Forty-two teeth from three mongrel dogs were divided into two equal groups. After three months, the animals were sacrificed to evaluate teeth radiographically using cone-beam computerized tomography, histopathologically, and real-time PCR for dentin sialophosphoprotein (DSPP), matrix extracellular phosphoglycoprotein (MEPE), and nestin (NES) mRNA expression. Radiographically, hard tissue formation was evident in both groups without significant differences (p = 0.440). Histopathologic findings confirmed the dentin bridge formation in both groups; however, such mineralized tissues were homogenous without cellular inclusions in the PRP group, while was osteodentin type in the MTA group. There was no significant difference in dentin bridge thickness between the PRP-capped and MTA-capped teeth (p = 0.732). The PRP group had significantly higher DSPP, MEPE, and NES mRNA gene expression than the MTA group (p < 0.05). In conclusion, PRP enables mineralized tissue formation following DPC similar to MTA, and could generate better cellular dentinogenic responses and restore dentin with homogenous architecture than MTA, making PRP a promising alternative DPC agent.

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“…All authors agree on the need to preserve as much of the pulp rich in coronal cells; this strategy increases the chances of healing due to physiological dentin deposition in the amputated area. Hemostasis, in the case of healthy pulp, should occur within 4–10 min, although different times are reported in the literature; if hemostasis is not achieved, more invasive treatment may be necessary [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Partial Pulpotomy in Young Permanent Teeth: A Systematic Review and Meta-Analysis

Camoni,

Cagetti,

Cirio

et al. 2023

Children

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The aim of the present systematic review was to evaluate the clinical and radiographic success of partial pulpotomies in deep caries processes or post-eruptive defects in young, vital permanent teeth. Four electronic databases, PubMed, Scopus, Embase, and Google Scholar, were searched, followed by a manual search in the reference lists. Randomized controlled trials evaluating partial pulpotomy with a follow-up period of ≥12 months were included. A meta-analysis using a random effects model was performed. A total of 3127 articles were retrieved, and after duplicate removal, 2642 were screened by title and abstract; 1 additional article was found during the manual search, and 79 were identified. Finally, six papers were included in the review. Regardless of the partial pulpotomy modalities or material used, there were no significant differences between clinical and radiographic success rates (cumulative success rate 91.8–92.3%). Five studies were included in the meta-analysis that did not indicate any statistically significant differences in success rates when mineral trioxide aggregate was compared to other materials (95% confidence interval: 0.239 to 1.016; p = 0.055). The present research systematically evaluates the evidence and summarizes the available data on partial pulpotomy in young permanent teeth. Given its high clinical and radiographic success rate, partial pulpotomy should be considered when vital pulpal therapy needs to be performed in highly damaged young permanent teeth, as this procedure provides a biological benefit and allows more invasive endodontic treatments to be postponed.

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Direct pulp capping procedures – Evidence and practice

Cited by 23 publications

References 151 publications

Dentine Remineralisation Induced by “Bioactive” Materials through Mineral Deposition: An In Vitro Study

Dentine Remineralisation Induced by “Bioactive” Materials through Mineral Deposition: An In Vitro Study

An animal study on the effectiveness of platelet-rich plasma as a direct pulp capping agent

Partial Pulpotomy in Young Permanent Teeth: A Systematic Review and Meta-Analysis

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