Direct Immunofluorescence of Plucked Hair in Pemphigus

Schaerer, Leo

doi:10.1001/archderm.139.2.228

Cited by 31 publications

(35 citation statements)

References 3 publications

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“…[44,45] As ORS is the continuation of the epidermis, DIF positivity in the epidermis of a biopsied specimen will be present in the ORS of the plucked hair also. Pemphigus antigen is expressed in whole ORS as well as in dermal bulb matrix.…”

Section: Diagnosismentioning

confidence: 99%

Pemphigus in India

Kanwar¹,

De²

2011

Indian J Dermatol Venereol Leprol

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Pemphigus is a chronic epidermal immunobullous disease with potentially fatal outcome. The journey of literature on pemphigus in India has come a long way in last five decades. Pemphigus in Indian patients has unique genetic, clinical, and epidemiological differences from those in the Western countries. Corticosteroids remain the mainstay of treatment for pemphigus. Dexamethasone-cyclophosphamide pulse therapy has revolutionized the management of pemphigus in India and abroad for nearly 3 decades now. Corticosteroid-based treatment, along with adjuvants, has significantly brought down the high mortality rates that had been observed in precorticosteroid era. Present day research is largely based on elucidating the pathogenesis beyond the antidesmoglein antibodies, and newer diagnostic and treatment approaches. In this article, we review various aspects of literature on pemphigus in India, on Indians abroad, or literature from other countries that are considered relevant to the topic.

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Section: Diagnosismentioning

confidence: 99%

Pemphigus in India

Kanwar¹,

De²

2011

Indian J Dermatol Venereol Leprol

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“…Hence finding a less-invasive way for collecting a suitable substrate would be of much help. Recently, Schaerer and Tr€ ueb 5 showed that outer root sheath (ORS) of plucked anagen hair can be used as substrate for DIF in the diagnosis of pemphigus. The value of this method was proven in further studies on patients with untreated or relapsed pemphigus.…”

mentioning

confidence: 99%

Direct immunofluorescence of plucked hair for evaluation of immunologic remission in pemphigus vulgaris

Daneshpazhooh

Naraghi

Ramezani

et al. 2011

Journal of the American Academy of Dermatology

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“…[26] The pemphigus-specific immunofluorescence pattern seen in the skin has also been demonstrated in the outer root sheaths of plucked hair follicles in 85-100% cases of PV. [28][29][30][31][32] The role of DIF techniques on Tzanck smear samples has also been evaluated for the diagnosis of PV, and the results were found to be comparable with respective skin biopsies in the same set of patients. [33] Thus, Tzanck smears can serve as an alternative to surgical biopsies especially in rural areas lacking proper histological equipment.…”

Section: Pemphigusmentioning

confidence: 99%

Immunofluorescence in dermatology

Chhabra¹,

Minz²,

Saikia³

2012

Indian J Dermatol Venereol Leprol

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Direct immunofluorescence (DIF) and indirect immunofluorescence (IIF) tests on skin biopsy are being done mostly in academic teaching hospitals. These tests provide a useful diagnostic aid to dermatologists. Immunohistology and serology can, in conjunction with histology, provide considerable help in delineation and diagnosis of various skin disorders as well as systemic diseases with skin involvement, e.g. systemic lupus erythematosus. Immunofluorescence (IF) studies have now become an invaluable supplement to clinical and histological examination in a variety of dermatological diseases. These skin diseases now include not only bullous and connective tissue disorders, vasculitides, and conditions such as lichen planus, but also the scaling dermatoses, notably psoriasis. In this review article, we share our experience of providing such a diagnostic facility for more than 30 years in a large tertiary care health center in North India and also help to outline the conditions, which can be diagnosed confidently, and others where IF can help in confirming a diagnosis or the immune component of the disease. The article also deals with handling of skin biopsy specimens and interpretation of biopsy findings on DIF and IIF examination.

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Direct Immunofluorescence of Plucked Hair in Pemphigus

Cited by 31 publications

References 3 publications

Pemphigus in India

Pemphigus in India

Direct immunofluorescence of plucked hair for evaluation of immunologic remission in pemphigus vulgaris

Immunofluorescence in dermatology

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